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The Pursuit of New Treatments for Focal Segmental Glomerulosclerosis: Harmonizing Innovation With the DUET Study of Sparsentan.

作者信息

Mishra Aparajita, Itoku Ai, Reidy Kimberly, Kaskel Frederick

机构信息

Division of Pediatric Nephrology, Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, New York.

出版信息

Kidney Med. 2024 May 22;6(6):100844. doi: 10.1016/j.xkme.2024.100844. eCollection 2024 Jun.

DOI:10.1016/j.xkme.2024.100844
PMID:38840848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11151161/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f1/11151161/0d8edc67757d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f1/11151161/0d8edc67757d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f1/11151161/0d8edc67757d/gr1.jpg

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The Pursuit of New Treatments for Focal Segmental Glomerulosclerosis: Harmonizing Innovation With the DUET Study of Sparsentan.局灶节段性肾小球硬化症新疗法的探索:将创新与司帕生坦的DUET研究相结合。
Kidney Med. 2024 May 22;6(6):100844. doi: 10.1016/j.xkme.2024.100844. eCollection 2024 Jun.
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Sparsentan for Focal Segmental Glomerulosclerosis in the DUET Open-Label Extension: Long-term Efficacy and Safety.司帕生坦用于局灶节段性肾小球硬化症的DUET开放标签扩展研究:长期疗效和安全性
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Implications of Complete Proteinuria Remission at any Time in Focal Segmental Glomerulosclerosis: Sparsentan DUET Trial.局灶节段性肾小球硬化症中任何时间完全蛋白尿缓解的意义:司帕生坦DUET试验
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本文引用的文献

1
Sparsentan for Focal Segmental Glomerulosclerosis in the DUET Open-Label Extension: Long-term Efficacy and Safety.司帕生坦用于局灶节段性肾小球硬化症的DUET开放标签扩展研究:长期疗效和安全性
Kidney Med. 2024 Apr 26;6(6):100833. doi: 10.1016/j.xkme.2024.100833. eCollection 2024 Jun.
2
Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today.肾小球疾病中 NEPTUNE 匹配研究网络(NEPTUNE)的原理和设计:今天,为合适的患者设计合适的试验。
Kidney Int. 2024 Feb;105(2):218-230. doi: 10.1016/j.kint.2023.11.018.
3
Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.
司帕生坦与厄贝沙坦治疗局灶节段性肾小球硬化症的比较
N Engl J Med. 2023 Dec 28;389(26):2436-2445. doi: 10.1056/NEJMoa2308550. Epub 2023 Nov 3.
4
Implications of Complete Proteinuria Remission at any Time in Focal Segmental Glomerulosclerosis: Sparsentan DUET Trial.局灶节段性肾小球硬化症中任何时间完全蛋白尿缓解的意义:司帕生坦DUET试验
Kidney Int Rep. 2023 Aug 4;8(10):2017-2028. doi: 10.1016/j.ekir.2023.07.022. eCollection 2023 Oct.
5
Novel Treatment Paradigms: Focal Segmental Glomerulosclerosis.新型治疗模式:局灶节段性肾小球硬化症
Kidney Int Rep. 2022 Oct 8;8(1):30-35. doi: 10.1016/j.ekir.2022.10.004. eCollection 2023 Jan.
6
The first randomized controlled trial in pediatric nephrology: the history of the International Study of Kidney Disease in Children (ISKDC).儿科肾脏病学领域的首个随机对照试验:儿童肾脏病国际研究(ISKDC)的历史。
Pediatr Nephrol. 2023 Dec;38(12):3947-3954. doi: 10.1007/s00467-022-05838-1. Epub 2023 Jan 10.
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IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome.国际儿科肾病学会关于儿童激素耐药型肾病综合征诊断和治疗的临床实践推荐意见。
Pediatr Nephrol. 2020 Aug;35(8):1529-1561. doi: 10.1007/s00467-020-04519-1. Epub 2020 May 7.
8
DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS.DUET 研究:一项评估 Sparsentan 在 FSGS 患者中的疗效和安全性的 2 期研究。
J Am Soc Nephrol. 2018 Nov;29(11):2745-2754. doi: 10.1681/ASN.2018010091.
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