McLellan Janna, Croen Lisa, Iosif Ana-Maria, Yoshida Cathleen, Ashwood Paul, Yolken Robert H, Van de Water Judy
Department of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, United States.
Kaiser Permanente Research Division, Oakland, CA, United States.
Front Psychiatry. 2024 May 22;15:1348092. doi: 10.3389/fpsyt.2024.1348092. eCollection 2024.
Maternal autoimmunity, and more specifically, the production of specific maternal autoantibodies, has been associated with altered offspring neurodevelopment. Maternal autoantibody-related (MAR) autism is a subtype of autism that is linked to gestational exposure to certain combinations of autoantibodies to proteins known to be important for fetal neurodevelopment. We wanted to address whether mothers with autism-specific patterns of autoantibodies have a skewed cytokine and chemokine profile during an immune response to infection. To do so, we examined a subset of mothers from the Early Markers for Autism (EMA) study who either produced known patterns of MAR autoantibodies (MAR+) or did not (MAR-). We compared the cytokine/chemokine profiles of MAR+ and MAR- mothers in the context of positive immunoglobulin G (IgG) reactivity to several viral and parasitic agents. We observed that MAR+ mothers have a higher level of proinflammatory cytokine interferon-gamma regardless of IgG status. Additionally, when comparing MAR+ and MAR- mothers in the context of the different pathogens, MAR+ mothers consistently had increases in multiple proinflammatory cytokines and chemokines.
母体自身免疫，更具体地说，特定母体自身抗体的产生，与后代神经发育改变有关。母体自身抗体相关（MAR）自闭症是自闭症的一种亚型，与孕期接触某些对胎儿神经发育重要的蛋白质的自身抗体组合有关。我们想研究具有自闭症特异性自身抗体模式的母亲在对感染的免疫反应过程中细胞因子和趋化因子谱是否存在偏差。为此，我们检查了自闭症早期标志物（EMA）研究中的一部分母亲，她们要么产生已知模式的MAR自身抗体（MAR+），要么不产生（MAR-）。我们在对几种病毒和寄生虫制剂的免疫球蛋白G（IgG）反应呈阳性的情况下，比较了MAR+和MAR-母亲的细胞因子/趋化因子谱。我们观察到，无论IgG状态如何，MAR+母亲的促炎细胞因子干扰素-γ水平都较高。此外，在比较不同病原体情况下的MAR+和MAR-母亲时，MAR+母亲的多种促炎细胞因子和趋化因子持续增加。
