Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen, China.
The Sixth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
Front Endocrinol (Lausanne). 2024 May 22;15:1367621. doi: 10.3389/fendo.2024.1367621. eCollection 2024.
Although there is solid epidemiological evidence supporting the connection between hypertension and gout, little has been said about the relationship between diastolic and systolic blood pressure and gout, the causal relationship and direction associated are uncertain, so we aim to research the causal relationship between diastolic and systolic blood pressure and gout.
We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal effect between 2 blood pressure phenotypes (including diastolic blood pressure and systolic blood pressure) and 5 gout phenotypes (including gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout) using genome-wide association study statistics. The inverse variance weighting method was used to generate the main results, while sensitivity analyses using MR-Egger, weighted median, Cochran's Q test, Egger intercept test, and leave-one-out analysis, were performed to assess the stability and reliability of the results.
After the screening, we found a causal relationship between diastolic blood pressure and gout, idiopathic gout, unspecified gout, and strictly defined gout, and a causal relationship between systolic blood pressure and gout, idiopathic gout, unspecified gout, and strictly defined gout.
From a genetic predisposition, controlling blood pressure may reduce the risk of gout.
尽管有确凿的流行病学证据支持高血压与痛风之间的关联，但关于舒张压和收缩压与痛风之间的关系、相关的因果关系和方向却知之甚少，因此我们旨在研究舒张压和收缩压与痛风之间的因果关系。
我们进行了两样本 Mendelian 随机化 (MR) 分析，使用全基因组关联研究统计数据来评估 2 种血压表型（包括舒张压和收缩压）与 5 种痛风表型（包括痛风、药物诱导性痛风、特发性痛风、未特指痛风和严格定义的痛风）之间的因果关系。使用逆方差加权法生成主要结果，同时使用 MR-Egger、加权中位数、Cochran's Q 检验、Egger 截距检验和逐一剔除分析进行敏感性分析，以评估结果的稳定性和可靠性。
经过筛选，我们发现舒张压与痛风、特发性痛风、未特指痛风和严格定义的痛风之间存在因果关系，收缩压与痛风、特发性痛风、未特指痛风和严格定义的痛风之间也存在因果关系。
从遗传易感性的角度来看，控制血压可能会降低痛风的风险。
