Teule G J, van Lingen A, Schneider A J, Verwey van Vught M A, Kester A D, Heidendal G A, Thijs L G
Circ Shock. 1985;15(3):185-92.
In anesthesized pigs, hemodynamic measurements and gated bloodpool scintigraphy were performed during and after infusion of live Escherichia coli (2 X 10(8)/kg). Ejection fractions (EF) as well as the relation between end-diastolic volumes (EDV) and stroke work (SW) were used to evaluate changes in left (LV) and right ventricular (RV) function. Porcine E. coli sepsis proved to be characterized by pulmonary vascular hypertension (PVH) and systemic arterial hypotension, accompanied by a reflex increase in heart rate. Systemic flow remained essentially unchanged. E. coli infusion resulted in pronounced and opposite changes in LV and RV preload. RVEDV increased initially and then returned to the value observed before E. coli infusion. LVEDV showed a continuous decrease during the observation of 3 hours. Alterations in LVSW and RVSW appeared to parallel the changes in LVEDV and RVEDV. No significant changes in LVEF and RVEF were found. It is concluded that porcine E. coli sepsis might be a suitable model for human sepsis complicated by PVH. In this animal model no clear signs of myocardial depression or evidence of right heart failure were observed.
在麻醉猪中，在输注活大肠杆菌（2×10⁸/kg）期间及之后进行血流动力学测量和门控心血池闪烁显像。射血分数（EF）以及舒张末期容积（EDV）与每搏功（SW）之间的关系用于评估左心室（LV）和右心室（RV）功能的变化。猪大肠杆菌败血症的特征为肺血管高压（PVH）和体循环动脉低血压，并伴有心率反射性增加。全身血流量基本保持不变。大肠杆菌输注导致LV和RV前负荷出现明显相反的变化。RVEDV最初增加，然后恢复到大肠杆菌输注前观察到的值。在3小时的观察期内，LVEDV持续下降。LVSW和RVSW的变化似乎与LVEDV和RVEDV的变化平行。未发现LVEF和RVEF有显著变化。结论是猪大肠杆菌败血症可能是人类并发PVH败血症的合适模型。在这个动物模型中，未观察到明显的心肌抑制迹象或右心衰竭的证据。
