在猪缺血再灌注模型中，非侵入性心脏 MRI 测量的左心室心肌功能与侵入性压力-容积参数的相关性。
Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model.
机构信息
From the Centre for Heart Research, Westmead Institute for Medical Research, 176 Hawkesbury Rd, Westmead, Sydney, NSW 2145, Australia (T.D., D.S., S.T., J.J.H.C.); Department of Cardiology, Westmead Hospital, Westmead, Australia (T.D., D.S., S.T., O.A., L.T., J.J.H.C.); Sydney School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia (T.D., D.S., S.T., L.T., J.J.H.C.); Cardiovascular Discovery Group, Kolling Institute, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, Australia (G.A.F.); Department of Cardiology, St Vincent's Hospital, Darlinghurst, Australia (M.F.); Cardiac Mechanics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, Australia (M.F.); Imaging and Phenotyping Laboratory, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Sydney, Australia (S.M.G.); Department of Radiology, Royal Prince Alfred Hospital, Camperdown, Australia (S.M.G.); Nepean Clinical School of Medicine, Charles Perkin Centre Nepean, University of Sydney, Kingswood, Australia (F.P.); and Department of Cardiology, Nepean Hospital, Kingswood, Australia (F.P.).
出版信息
Radiol Cardiothorac Imaging. 2024 Jun;6(3):e230252. doi: 10.1148/ryct.230252.
Purpose To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods Sixteen adult female swine were induced with MI, with six swine used as controls and 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of cardiac function, including slopes of end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW), were obtained on day 28 after MI. Cardiac MRI was performed on day 2 and day 28 after infarct. Global longitudinal strain (GLS) and global circumferential strain (GCS) were measured. Ventriculo-arterial coupling (VAC) was derived from PV loop and cardiac MRI data. Pearson correlation analysis was performed. Results GCS ( = 0.60, = .01), left ventricular ejection fraction (LVEF) ( = 0.60, = .01), and cardiac MRI-derived VAC ( = 0.61, = .01) had a significant linear relationship with ESPVR. GCS ( = 0.75, < .001) had the strongest significant linear relationship with PRSW, followed by LVEF ( = 0.67, = .005) and cardiac MRI-derived VAC ( = 0.60, = .01). GLS was not significantly correlated with ESPVR or PRSW. There was a linear correlation ( = 0.82, < .001) between VAC derived from cardiac MRI and from PV loop data. GCS (-3.5% ± 2.3 vs 0.5% ± 1.4, = .007) and cardiac MRI-derived VAC (-0.6 ± 0.6 vs 0.3 ± 0.3, = .001) significantly improved in the animals treated with PDGF-AB 28 days after MI compared with controls. Conclusion Cardiac MRI-derived parameters of MI correlated with invasive PV measures, with GCS showing the strongest correlation. Cardiac MRI-derived measures also demonstrated utility in assessing therapeutic benefit using PDGF-AB. Cardiac MRI, Myocardial Infarction, Pressure Volume Loop, Strain Imaging, Ventriculo-arterial Coupling © RSNA, 2024.
目的 评估心脏磁共振衍生参数与压力-容积（PV）环数据之间的相关性，并评估心肌梗死后左心室功能的变化。 材料与方法 16 头成年雌性猪诱导心肌梗死，其中 6 头作为对照，10 头接受血小板衍生生长因子-AB（PDGF-AB）治疗。在心肌梗死后第 28 天获得包括收缩末期压力-容积关系（ESPVR）斜率和预负荷可诱导的工作（PRSW）在内的心脏功能无负荷指标。心脏磁共振于梗死后第 2 天和第 28 天进行。测量整体纵向应变（GLS）和整体周向应变（GCS）。从 PV 环和心脏 MRI 数据中得出心室-动脉偶联（VAC）。进行 Pearson 相关性分析。 结果 GCS（ = 0.60， =.01）、左心室射血分数（LVEF）（ = 0.60， =.01）和心脏 MRI 衍生的 VAC（ = 0.61， =.01）与 ESPVR 呈显著线性关系。GCS（ = 0.75， <.001）与 PRSW 呈最强显著线性关系，其次是 LVEF（ = 0.67， =.005）和心脏 MRI 衍生的 VAC（ = 0.60， =.01）。GLS 与 ESPVR 或 PRSW 无显著相关性。心脏 MRI 和 PV 环数据得出的 VAC 呈线性相关（ = 0.82， <.001）。在心肌梗死后 28 天接受 PDGF-AB 治疗的动物中，GCS（-3.5%±2.3 比 0.5%±1.4， =.007）和心脏 MRI 衍生的 VAC（-0.6±0.6 比 0.3±0.3， =.001）显著改善。 结论 心脏 MRI 衍生的 MI 参数与侵入性 PV 测量相关，其中 GCS 相关性最强。心脏 MRI 衍生的参数也可用于评估 PDGF-AB 治疗的疗效。 心脏磁共振、心肌梗死、压力-容积环、应变成像、心室-动脉偶联 © RSNA，2024。
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