Department of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, Minnesota.
Department of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, Minnesota; Medical Scientist Training Program, Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota.
Heart Rhythm. 2024 Jul;21(7):1083-1088. doi: 10.1016/j.hrthm.2024.02.018. Epub 2024 Jun 6.
Energy drinks potentially can trigger life-threatening cardiac arrhythmias. It has been postulated that the highly stimulating and unregulated ingredients alter heart rate, blood pressure, cardiac contractility, and cardiac repolarization in a potentially proarrhythmic manner.
The purpose of this study was to describe our experience regarding sudden cardiac arrest (SCA) occurring in proximity to energy drink consumption in patients with underlying genetic heart diseases.
The electronic medical records of all SCA survivors with proven arrhythmias referred to the Mayo Clinic Windland Smith Rice Genetic Heart Rhythm Clinic for evaluation were reviewed to identify those who consumed an energy drink before their event. Patient demographics, clinical characteristics, documented energy drink consumption, and temporal relationship of energy drink consumption to SCA were obtained.
Among 144 SCA survivors, 7 (5%; 6 female; mean age at SCA 29 ± 8 years) experienced an unexplained SCA associated temporally with energy drink consumption. Of these individuals, 2 had long QT syndrome and 2 had catecholaminergic polymorphic ventricular tachycardia; the remaining 3 were diagnosed with idiopathic ventricular fibrillation. Three patients (43%) consumed energy drinks regularly. Six patients (86%) required a rescue shock, and 1 (14%) was resuscitated manually. All SCA survivors have quit consuming energy drinks and have been event-free since.
Overall, 5% of SCA survivors experienced SCA in proximity to consuming an energy drink. Although larger cohort studies are needed to elucidate the incidence/prevalence and quantify its precise risk, it seems prudent to sound an early warning on this potential risk.
能量饮料可能会引发危及生命的心律失常。据推测，高度刺激和不受监管的成分以潜在致心律失常的方式改变心率、血压、心肌收缩力和心肌复极。
本研究旨在描述我们在患有潜在遗传性心脏病的患者中发生的与能量饮料消费密切相关的突发性心脏骤停 (SCA) 的经验。
回顾了所有因心律失常而被转诊到梅奥诊所 Windland Smith Rice 遗传心脏节律诊所进行评估的 SCA 幸存者的电子病历，以确定那些在事件发生前饮用能量饮料的患者。获取患者人口统计学、临床特征、记录的能量饮料消费以及能量饮料消费与 SCA 的时间关系。
在 144 名 SCA 幸存者中，有 7 名（5%；6 名女性；SCA 时的平均年龄为 29 ± 8 岁）经历了与能量饮料消费有关的不明原因的 SCA。这些人中，2 人患有长 QT 综合征，2 人患有儿茶酚胺多形性室性心动过速；其余 3 人被诊断为特发性室颤。3 名患者（43%）经常饮用能量饮料。6 名患者（86%）需要急救电击，1 名患者（14%）需要手动复苏。所有 SCA 幸存者已停止饮用能量饮料，且自那时起无事件发生。
总体而言，5%的 SCA 幸存者在饮用能量饮料后发生 SCA。尽管需要更大的队列研究来阐明发病率/患病率并量化其确切风险，但似乎有必要对这种潜在风险发出早期警告。
