Sachse G, Mäser E, Federlin K
Dtsch Med Wochenschr. 1985 Mar 15;110(11):403-6. doi: 10.1055/s-2008-1068835.
During in-patient admission after metabolic stabilisation insulin treatment of 32 type-1-diabetics was changed from bovine insulin (Depot-Insulin Hoechst CR) to semisynthetic human insulin of the intermediary type (Depot-H-Insulin Hoechst). Out-patient follow-up over a period of 12 months showed constant satisfactory mean day blood sugar values and morning postprandial blood sugar. 14 patients, however, showed significantly increased fasting blood sugar values which could be adjusted after change of evening insulin injections to the longer acting NPH insulin without normal insulin admixture (Basal-H-insulin Hoechst). In addition, a slight but not significant reduction of daily insulin requirements could be noted. There was no change of the relation between morning and evening insulin dosage. Hypoglycaemias did not occur significantly more frequently and hypoglycaemic symptoms showed no alterations.
在32例1型糖尿病患者代谢稳定后住院期间，胰岛素治疗从牛胰岛素（赫斯特长效胰岛素）改为中效半合成人胰岛素（赫斯特长效人胰岛素）。12个月的门诊随访显示，日间平均血糖值和早餐后血糖一直令人满意。然而，14例患者空腹血糖值显著升高，在将晚间胰岛素注射改为不含普通胰岛素混合的长效中性鱼精蛋白锌胰岛素（赫斯特基础人胰岛素）后，空腹血糖值得到了调整。此外，每日胰岛素需求量略有下降，但不显著。早晚胰岛素剂量之间的关系没有变化。低血糖症的发生频率没有显著增加，低血糖症状也没有改变。
