School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Fitoterapia. 2024 Sep;177:106057. doi: 10.1016/j.fitote.2024.106057. Epub 2024 Jun 4.
The pericarps of Zanthoxylum schinifolium Sieb. et Zucc were called "green huajiao", which were used as traditional folk medicine and popular seasoning in China. In this study, twenty-seven alkylamides, including a rare alkylamide containing two amide groups (1), an alkylamide with a furan ring (5), six new alkylamide analogues (2-4, 6-8), together with nineteen known alkylamides (9-27) were isolated from green huajiao. Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and UV spectra. Furthermore, compounds 5, 18, 21, and 22 exhibited weak protective activity for corticosterone-induced PC12 cells damage.
花椒的外果皮被称为“青花椒”，在中国被用作传统民间药物和流行的调味料。在这项研究中，从青花椒中分离得到了二十七个烷酰胺，包括一个罕见的含有两个酰胺基团的烷酰胺（1）、一个具有呋喃环的烷酰胺（5）、六个新的烷酰胺类似物（2-4、6-8），以及十九个已知的烷酰胺（9-27）。它们的结构通过广泛的光谱分析，包括 1D、2D NMR、HRESIMS 和 UV 光谱来阐明。此外，化合物 5、18、21 和 22 对皮质酮诱导的 PC12 细胞损伤表现出较弱的保护活性。
