Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Int J Biol Macromol. 2024 Jun;272(Pt 2):132888. doi: 10.1016/j.ijbiomac.2024.132888. Epub 2024 Jun 4.
Lung cancer (LC) is a crisis of catastrophic proportions. It is a global problem and urgently requires a solution. The classic chemo drugs are lagging behind as they lack selectivity, where their side effects are spilled all over the body, and these adverse effects would be terribly tragic for LC patients. Therefore, they could make a bad situation worse, inflict damage on normal cells, and inflict pain on patients. Since our confidence in classic drugs is eroding, chitosan can offer a major leap forward in LC therapy. It can provide the backbone and the vehicle that enable chemo drugs to penetrate the hard shell of LC. It could be functionalized in a variety of ways to deliver a deadly payload of toxins to kill the bad guys. It is implemented in formulation of polymeric NPs, lipidic NPs, nanocomposites, multiwalled carbon nanotubes, and phototherapeutic agents. This review is a pretty clear proof of chitosan's utility as a weapon in battling LC. Chitosan-based formulations could work effectively to kill LC cells. If a researcher is looking for a vehicle for medication for LC therapy, chitosan can be an appropriate choice.
肺癌（LC）是一场灾难性的危机。这是一个全球性的问题，迫切需要解决方案。经典的化疗药物缺乏选择性，其副作用会波及全身，这对 LC 患者来说是极其悲惨的。因此，它们可能会使情况恶化，损害正常细胞，给患者带来痛苦。由于我们对经典药物的信心正在减弱，壳聚糖可以在 LC 治疗方面取得重大突破。它可以为化疗药物穿透 LC 的坚硬外壳提供骨干和载体。它可以通过多种方式进行功能化，将致命的毒素有效载荷传递给杀死坏人。它被应用于聚合物 NPs、脂质体 NPs、纳米复合材料、多壁碳纳米管和光疗剂中。这篇综述清楚地证明了壳聚糖作为对抗 LC 的武器的实用性。基于壳聚糖的制剂可以有效地杀死 LC 细胞。如果研究人员正在寻找用于 LC 治疗的药物载体，壳聚糖可能是一个合适的选择。
