116例不同梅毒分期患者中特异性IgM抗体的重要性
Importance of specific IgM antibodies in 116 patients with various stages of syphilis.
作者信息
Merlin S, Andre J, Alacoque B, Paris-Hamelin A
出版信息
Genitourin Med. 1985 Apr;61(2):82-7. doi: 10.1136/sti.61.2.82.
We tested 222 serum samples obtained from 51 patients presenting with syphilis, before and after treatment; 117 from 65 patients with a history of syphilis (114) or yaws (3); 77 from 71 patients with no evidence of syphilis; and 1117 serologically negative serum samples. Our tests included the IgM fluorescent treponemal antibody absorbed (IgM-FTA-ABS) and solid phase haemadsorption assay (SPHA) techniques. According to the stage of development of syphilis, IgM antibodies were found in 83-100% of the serum samples. This permitted a precise diagnosis to be made and cure assessed. As IgM antibodies were absent in serum from patients with healed syphilis, resolved syphilis could be distinguished from developing syphilis. The sensitivity (92%) of the IgM-FTA-ABS test was comparable with that of the SPHA (96%), but the SPHA was more specific (97.4%) than the IgM-FTA-ABS test (89.61%).
我们检测了从51例梅毒患者治疗前后获取的222份血清样本；从65例有梅毒病史（114例）或雅司病病史（3例）的患者中获取的117份血清样本；从71例无梅毒迹象的患者中获取的77份血清样本；以及1117份血清学阴性的血清样本。我们的检测包括IgM荧光密螺旋体抗体吸收试验（IgM-FTA-ABS）和固相血细胞吸附试验（SPHA）技术。根据梅毒的发展阶段，在83%-100%的血清样本中发现了IgM抗体。这使得能够做出精确诊断并评估治愈情况。由于治愈的梅毒患者血清中不存在IgM抗体，因此可以将已治愈的梅毒与正在发展的梅毒区分开来。IgM-FTA-ABS试验的敏感性（92%）与SPHA试验（96%）相当，但SPHA试验比IgM-FTA-ABS试验（89.61%）更具特异性（97.4%）。
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