School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
ICF International Inc, Atlanta, Georgia, USA.
Cancer Med. 2024 Jun;13(11):e7313. doi: 10.1002/cam4.7313.
Cancer-related fatigue (CRF) and fear of cancer recurrence (FCR) are two common concerns experienced by cancer survivors. However, the relationship between these two concerns is poorly understood, and whether CRF and FCR influence each other over time is unclear.
Data were from a national, prospective, longitudinal study, the American Cancer Society's Study of Cancer Survivors-I (SCS-I). Surveys were completed by 1395 survivors of 10 different cancer types at three time-points, including assessment 1.3 years (T1), 2.2 years (T2) and 8.8 years (T3) following their cancer diagnosis. CRF was assessed using the fatigue-inertia subscale of the Profile of Mood States, and FCR by the FCR subscale of the Cancer Problems in Living Scale. Multiple group random intercepts cross-lagged panel models investigated prospective associations between CRF and FCR.
For younger participants (at or below median age of 55 years, n = 697), CRF at T1 and T2 marginally and significantly predicted FCR at T2 and T3, respectively, but no lagged effects of FCR on subsequent CRF were observed. Cross-lagged effects were not observed for survivors over 55 years of age.
Both CRF and FCR are debilitating side effects of cancer and its treatments. Given that CRF may be predictive of FCR, it possible that early detection and intervention for CRF could contribute to lowering FCR severity.
癌症相关疲劳（CRF）和对癌症复发的恐惧（FCR）是癌症幸存者常见的两个担忧。然而，这两个关注点之间的关系尚不清楚，CRF 和 FCR 是否会随着时间的推移相互影响也不清楚。
数据来自一项全国性、前瞻性、纵向研究，即美国癌症协会的癌症幸存者研究-I（SCS-I）。共有 1395 名来自 10 种不同癌症类型的幸存者在三个时间点完成了调查，包括癌症诊断后 1.3 年（T1）、2.2 年（T2）和 8.8 年（T3）。CRF 使用状态特征简表的疲劳-惰性子量表进行评估，FCR 使用癌症生活问题量表的 FCR 子量表进行评估。多组随机截距交叉滞后面板模型调查了 CRF 和 FCR 之间的前瞻性关联。
对于年龄较小的参与者（年龄在 55 岁或以下，n=697），T1 和 T2 的 CRF 分别微弱且显著地预测了 T2 和 T3 的 FCR，但没有观察到 FCR 对随后的 CRF 的滞后影响。对于年龄超过 55 岁的幸存者，没有观察到交叉滞后效应。
CRF 和 FCR 都是癌症及其治疗的致残副作用。鉴于 CRF 可能是 FCR 的预测因素，早期检测和干预 CRF 可能有助于降低 FCR 的严重程度。
