Mustafa Amany I, Abdel-Halim Waleed A E, Osman Maha M, Rezk Shymaa M
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
Indian Dermatol Online J. 2024 Apr 29;15(3):431-436. doi: 10.4103/idoj.idoj_386_23. eCollection 2024 May-Jun.
Vitiligo is an immune-mediated, chronic skin condition that affects both the innate and adaptive immune systems. Antimicrobial peptide overexpression is one of its defining characteristics. Granulysin (GNLY), an antimicrobial peptide, may play a role in the pathogenesis of various autoimmune diseases.
To estimate the serum GNLY levels in vitiligo patients and to correlate those levels with the severity and activity of the disease.
This case-control study included 60 non-segmental vitiligo patients (Group A) and a control group of 60 people who were matched for age and sex, appeared to be in good health, and were not suffering from vitiligo (Group B). The serum granulysin levels of all subjects were measured using an enzyme-linked immunosorbent assay.
When compared to the control group, vitiligo patients had significantly higher serum GNLY levels ( = 0.001). When compared to patients with stable disease, those with active vitiligo had significantly higher serum GNLY levels ( = 0.008). Additionally, there was a positive correlation between the serum GNLY levels and the vitiligo area severity index and vitiligo disease activity scores ( = 0.004 and <0.001, respectively).
Study population was relatively small. Evaluation of serum granulysin before and after treatment could have been more beneficial.
Blood granulysin levels could contribute to the pathogenesis of vitiligo. A higher serum granulysin level may also be a trustworthy predictor of the severity and progression of a disease.
白癜风是一种免疫介导的慢性皮肤病，会影响先天性和适应性免疫系统。抗菌肽过表达是其特征之一。颗粒溶素（GNLY）作为一种抗菌肽，可能在多种自身免疫性疾病的发病机制中起作用。
评估白癜风患者血清中颗粒溶素（GNLY）水平，并将这些水平与疾病的严重程度和活动度相关联。
本病例对照研究纳入60例非节段型白癜风患者（A组）和60例年龄、性别匹配、看似健康且无白癜风的对照组人群（B组）。所有受试者的血清颗粒溶素水平采用酶联免疫吸附测定法进行检测。
与对照组相比，白癜风患者血清GNLY水平显著更高（P = 0.001）。与病情稳定的患者相比，活动期白癜风患者血清GNLY水平显著更高（P = 0.008）。此外，血清GNLY水平与白癜风面积严重指数及白癜风疾病活动评分之间存在正相关（分别为P = 0.004和P < 0.001）。
研究人群相对较小。治疗前后血清颗粒溶素的评估可能会更有益。
血液中颗粒溶素水平可能与白癜风的发病机制有关。较高的血清颗粒溶素水平也可能是疾病严重程度和进展的可靠预测指标。
