Chiriac Anca, Wollina Uwe
Department of Dermatology, Nicolina Medical Center, Iasi, Romania.
Apollonia University, Iasi, Romania.
Indian Dermatol Online J. 2024 Apr 23;15(3):383-391. doi: 10.4103/idoj.idoj_593_23. eCollection 2024 May-Jun.
Pediatric dermatitis seborrhoica (DS) is a common inflammatory disorder of infancy and adolescence distinct from atopic dermatitis. We performed a narrative review on clinical and therapeutic aspects of the disease. The prevalence varies geographically and can reach up to 10%. There is a slight male predominance. Although etiopathology is not well known, both endogenous and exogenous factors contribute. Skin microbiome and its interaction with sebaceous gland function is crucial. The inflammatory pathways include innate immune function and skin barrier disturbances. spp. and certain bacteria are increased in lesional skin. DS develops in different clinical subtypes, from localized cephalic to disseminated disease with a risk of erythroderma and eczema herpeticatum. Treatment consists of skin care and topical and rarely systemic medical therapy. Cornerstones of treatment are antifungals and mild corticosteroids. Targeted treatment is on the horizon. Pediatric DS is a common disorder important in the differential diagnosis of skin problems in infants and and children. Due to better understanding of its pathogenesis, new treatment options are developed.
小儿脂溢性皮炎（DS）是一种常见的婴幼儿及青少年炎症性疾病，与特应性皮炎不同。我们对该疾病的临床和治疗方面进行了叙述性综述。其患病率因地域而异，可达10%。男性略占优势。尽管病因尚不完全清楚，但内源性和外源性因素均有作用。皮肤微生物群及其与皮脂腺功能的相互作用至关重要。炎症途径包括先天性免疫功能和皮肤屏障紊乱。病变皮肤中某些细菌增多。DS有不同的临床亚型，从局限性头部病变到播散性疾病，有发生红皮病和疱疹样湿疹的风险。治疗包括皮肤护理以及局部治疗，很少采用全身药物治疗。治疗的基石是抗真菌药和温和的皮质类固醇。靶向治疗即将出现。小儿DS是一种常见疾病，在婴幼儿及儿童皮肤问题的鉴别诊断中很重要。由于对其发病机制有了更好的理解，正在开发新的治疗选择。
