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在一名患有关节炎、眼部症状和双侧腮腺肿大的儿童结节病病例中,肺部未受累导致诊断延迟3年。

Lack of pulmonary involvement leads to a 3 years delay of diagnosis in a childhood sarcoidosis case with arthritis, ocular symptoms, and bilateral parotid swelling.

作者信息

Fatih Mohammed Taib, Saleh Renaz Sabir, Majeed Truska Faraidun, Mahmood Mohammed Khalid

机构信息

Dentistry Department Komar University of Science and Technology Kurdistan Iraq.

College of Dentistry, Oral Diagnosis Department Sulaimani University Kurdistan Iraq.

出版信息

Clin Case Rep. 2024 Jun 5;12(6):e8982. doi: 10.1002/ccr3.8982. eCollection 2024 Jun.

DOI:10.1002/ccr3.8982
PMID:38845801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11154798/
Abstract

KEY CLINICAL MESSAGE

This paper presents a rare sarcoidosis case in a child of 12 years of age presented with arthritis, bilateral parotid enlargement and ocular, but unfortunately the diagnosis has been missed due to lack of pulmonary involvement.

ABSTRACT

Diagnosis of sarcoidosis is by exclusion, and sometimes, it can be challenging. This paper presents a rare sarcoidosis case in a child of 12 years of age presented with bilateral parotid enlargement. The signs of musculoskeletal and ocular involvement were present before the parotid enlargement, and the parotid swelling persisted for 3 years; but unfortunately the definite diagnosis has been missed by the previous healthcare professionals most probably due to the rarity of the situation, especially lack of pulmonary involvement. Therefore, cooperation between different healthcare specialties is important for an effective diagnosis and management. Despite its rarity, sarcoidosis should always be present in the list of differential diagnosis when encountering multisystem entities like arthritis, ocular symptoms and parotid swelling.

摘要

关键临床信息

本文介绍了一例12岁儿童的罕见结节病病例,该患儿出现关节炎、双侧腮腺肿大和眼部症状,但不幸的是,由于缺乏肺部受累表现,诊断被漏诊。

摘要

结节病的诊断需排除其他疾病,有时具有挑战性。本文介绍了一例12岁儿童的罕见结节病病例,该患儿出现双侧腮腺肿大。在腮腺肿大之前就已出现肌肉骨骼和眼部受累的体征,腮腺肿胀持续了3年;但不幸的是,之前的医护人员很可能由于这种情况罕见,尤其是缺乏肺部受累表现,而漏诊了明确诊断。因此,不同医疗专科之间的合作对于有效诊断和管理至关重要。尽管结节病罕见,但在遇到如关节炎、眼部症状和腮腺肿胀等多系统疾病时,鉴别诊断清单中应始终考虑到结节病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/1c73b06d0ab4/CCR3-12-e8982-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/682eede654dc/CCR3-12-e8982-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/48c31a09fbba/CCR3-12-e8982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/fd9f45ed5338/CCR3-12-e8982-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/00c704f3a990/CCR3-12-e8982-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/1c73b06d0ab4/CCR3-12-e8982-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/682eede654dc/CCR3-12-e8982-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/48c31a09fbba/CCR3-12-e8982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/fd9f45ed5338/CCR3-12-e8982-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/00c704f3a990/CCR3-12-e8982-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2cc/11154798/1c73b06d0ab4/CCR3-12-e8982-g002.jpg

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本文引用的文献

1
Joint involvement in sarcoidosis: systematic review and meta-analysis of prevalence, clinical pattern and outcome.结节病的关节受累:患病率、临床特征和结局的系统评价和荟萃分析。
Rheumatology (Oxford). 2024 Jul 1;63(7):1803-1814. doi: 10.1093/rheumatology/keae048.
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A clinical overview of paediatric sarcoidosis: Multicentre experience from Turkey.儿童结节病临床概述:来自土耳其的多中心经验。
Mod Rheumatol. 2024 Mar 28;34(3):639-645. doi: 10.1093/mr/road050.
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Pediatric Sarcoidosis: A Review with Emphasis on Early Onset and High-Risk Sarcoidosis and Diagnostic Challenges.
小儿结节病:一篇重点关注早发性和高危结节病及诊断挑战的综述
Diagnostics (Basel). 2019 Oct 25;9(4):160. doi: 10.3390/diagnostics9040160.
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Paediatric sarcoidosis.儿科类肉瘤病。
Paediatr Respir Rev. 2019 Feb;29:53-59. doi: 10.1016/j.prrv.2018.05.003. Epub 2018 May 19.
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Epidemiology of sarcoidosis: current findings and future directions.结节病的流行病学:当前研究结果与未来方向。
Ther Adv Chronic Dis. 2018 Aug 24;9(11):227-240. doi: 10.1177/2040622318790197. eCollection 2018 Nov.
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A Review of Chronic Granulomatous Disease.慢性肉芽肿病综述。
Adv Ther. 2017 Dec;34(12):2543-2557. doi: 10.1007/s12325-017-0636-2. Epub 2017 Nov 22.
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Ocular Sarcoidosis.眼部结节病
Clin Chest Med. 2015 Dec;36(4):669-83. doi: 10.1016/j.ccm.2015.08.009.
8
Lung sarcoidosis in children: update on disease expression and management.儿童肺结节病:疾病表现和治疗的最新进展。
Thorax. 2015 Jun;70(6):537-42. doi: 10.1136/thoraxjnl-2015-206825. Epub 2015 Apr 8.
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Childhood sarcoidosis: Louisiana experience.儿童结节病:路易斯安那州的经验。
Clin Rheumatol. 2016 Jul;35(7):1879-84. doi: 10.1007/s10067-015-2870-9. Epub 2015 Jan 24.
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Bilateral parotitis as the initial presentation of childhood sarcoidosis.双侧腮腺炎为儿童结节病的首发表现。
Am J Otolaryngol. 2013 Mar-Apr;34(2):142-4. doi: 10.1016/j.amjoto.2012.08.007. Epub 2012 Oct 23.