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胡椒碱-羟基苯甲酸酯作为植物化学抗骨关节炎组合：结构、溶解度及体内抗炎研究

Piperine-hydroxybenzoate as phytochemistry antiosteoarthritis combination: Structural, solubility, and in vivo antiinflammatory study.

作者信息

Sartinah Ari, Uekusa Hidehiro, Abekura Yuto, Ibrahim Slamet, Anggadiredja Kusnandar

机构信息

School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia.

Faculty of Pharmacy, Halu Oleo University, Kendari 93231, Indonesia.

出版信息

Heliyon. 2024 May 23;10(11):e31548. doi: 10.1016/j.heliyon.2024.e31548. eCollection 2024 Jun 15.

DOI:10.1016/j.heliyon.2024.e31548
PMID:38845875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11154213/
Abstract

This study discusses the composition and structure determination of a new multicomponent system from antiinflammatory natural ingredients, consisting of piperine (Pip) and 4-hydroxybenzoic acid (HBA), named Pip-HBA. In addition, this research studied its solubility and anti-inflammatory activity. After screening the stoichiometric proportions, this multicomponent system formation reaction was carried out using the solvent-dropped grinding and evaporation methods. Characterizations using solid analysis including differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR), confirmed the formation of Pip-HBA. These multicomponent systems showed different thermograms and diffractograms. Furthermore, the FTIR spectrum of Pip-HBA multicomponent system differs from the physical mixture and its constituent components. Single crystal diffractometry (SCXRD) determined Pip-HBA to be a new multicomponent system structure in three dimensions. Pip-HBA showed increased solubility and anti-inflammatory activity compared to single piperine. Therefore, Pip-HBA multicomponent system has quite potential for further preparation development.

摘要

本研究探讨了一种由抗炎天然成分组成的新型多组分体系的组成和结构测定，该体系由胡椒碱（Pip）和4-羟基苯甲酸（HBA）组成，命名为Pip-HBA。此外，本研究还对其溶解度和抗炎活性进行了研究。在筛选化学计量比后，采用溶剂滴磨法和蒸发法进行了该多组分体系的形成反应。使用包括差示扫描量热法（DSC）、粉末X射线衍射法（PXRD）和傅里叶变换红外光谱法（FTIR）在内的固体分析进行表征，证实了Pip-HBA的形成。这些多组分体系显示出不同的热谱图和衍射图。此外，Pip-HBA多组分体系的FTIR光谱与物理混合物及其组成成分不同。单晶衍射法（SCXRD）确定Pip-HBA为三维的新型多组分体系结构。与单一胡椒碱相比，Pip-HBA显示出更高的溶解度和抗炎活性。因此，Pip-HBA多组分体系在进一步的制剂开发方面具有相当大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/1b26f96b875d/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/807f7c5c4c73/gr3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/6c43f012a53a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/0a2929b93e8c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/8be55aa04c30/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/2781f8fe86cb/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/1b26f96b875d/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/5ea8706063a6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/164250d884db/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/807f7c5c4c73/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/a737d1f4d938/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/6c43f012a53a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/0a2929b93e8c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/8be55aa04c30/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/2781f8fe86cb/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/11154213/1b26f96b875d/gr9.jpg

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