Zhang Kaiping, Fang Xiang, Zhang Yin, Chao Min
Department of Urology, Anhui Provincial Children's Hospital/Children's Hospital of Fudan University (Affiliated Anhui Branch), Hefei, China.
Heliyon. 2024 May 23;10(11):e31902. doi: 10.1016/j.heliyon.2024.e31902. eCollection 2024 Jun 15.
Urinary tract infection (UTI) is a well-known bacterial infection posing serious health problem in children. A retrospective study was conducted to explore the uropathogen and its antibiotic resistance in children with UTI. Data of urine culture and antimicrobial susceptibility test was collected. Consequently, 840 children were included. The overall culture-positive UTI was 458 (54.52 %) with 166 (36.24 %), followed by 59 (12.88 %), 70 (15.28 %) and others. They were highly resistant to the most commonly used antibiotics. In 694 children with complicated UTI, there were 8 children with fungal infection. Multiple drug resistance (MDR) was recorded in 315 (80.98 %). The overall proportion of Extended Spectrum β-Lactamase (ESβL) production was 25 (6.43 %). In 146 children with simple UTI, MDR were also detected in 47 (77.05 %). There were 6 (9.84 %) positive for ESβL production. Our study found that complicated UTI was relatively common. was the most prevalent isolate, followed by and . These organisms were highly resistant to the most commonly used antibiotics. Relatively high prevalence of MDR and low ESβL-producing organisms were observed.
尿路感染（UTI）是一种众所周知的细菌感染，给儿童带来严重的健康问题。进行了一项回顾性研究，以探讨UTI患儿的尿路病原体及其抗生素耐药性。收集了尿培养和抗菌药敏试验的数据。结果，纳入了840名儿童。总体培养阳性的UTI为458例（54.52%），其中166例（36.24%），其次是59例（12.88%）、70例（15.28%）及其他。它们对最常用的抗生素具有高度耐药性。在694例复杂性UTI患儿中，有8例真菌感染。315例（80.98%）记录有多重耐药（MDR）。产超广谱β-内酰胺酶（ESβL）的总体比例为25例（6.43%）。在146例单纯性UTI患儿中，也检测到47例（77.05%）MDR。有6例（9.84%）产ESβL阳性。我们的研究发现，复杂性UTI相对常见。是最常见的分离株，其次是和。这些微生物对最常用的抗生素具有高度耐药性。观察到MDR的患病率相对较高，产ESβL的微生物患病率较低。
