Yanni Gema Nazri, Saragih Rina Amalia C, Lubis Aridamuriany Dwiputri
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara.
Acta Med Philipp. 2024 Apr 15;58(6):64-68. doi: 10.47895/amp.vi0.6496. eCollection 2024.
This study aims to assess the correlation of ferritin serum level and PELOD-2 score, and determine the effectiveness of ferritin serum level as early indicator of organ dysfunction.
This was a cross-sectional study carried out to pediatric patients with sepsis in the Pediatric Intensive Care Unit Haji Adam Malik and Universitas Sumatera Utara hospital from June 2021 - January 2022. Complete blood work was done, and ferritin serum level and PELOD-2 score were measured on the first and third day of hospital stay of all the sixty participants aged 1-18 years old with sepsis. The correlation was measured using Spearman test, with p<0.05 indicating a significant correlation.
The median level of serum ferritin level was 480 (24.7 - 22652) ng/mL. There were 20% patients with ferritin level <200 ng/mL, 26.7% with ferritin level 200-500 ng/mL, and 53.3% patients with ferritin >500 ng/mL. The median score of PELOD-2 was 4. There was a significant correlation of serum ferritin and PELOD-2 score on day 1 of hospital stay.
The ferritin serum level is effective as an early indicator of organ dysfunction until PELOD-2 score is established. There is a positive correlation between serum ferritin and PELOD-2 score. There is a link between elevated ferritin and worse disease prognosis.
本研究旨在评估血清铁蛋白水平与PELOD-2评分的相关性，并确定血清铁蛋白水平作为器官功能障碍早期指标的有效性。
这是一项横断面研究，于2021年6月至2022年1月在哈芝亚当·马利克儿科重症监护病房和北苏门答腊大学医院对脓毒症患儿进行。对所有60名年龄在1至18岁的脓毒症参与者在住院的第一天和第三天进行了全血细胞检查，并测量了血清铁蛋白水平和PELOD-2评分。使用Spearman检验测量相关性，p<0.05表示存在显著相关性。
血清铁蛋白水平的中位数为480（24.7 - 22652）ng/mL。铁蛋白水平<200 ng/mL的患者占20%，200-500 ng/mL的患者占26.7%，铁蛋白>500 ng/mL的患者占53.3%。PELOD-2的中位数评分为4。住院第一天血清铁蛋白与PELOD-2评分存在显著相关性。
在PELOD-2评分确立之前，血清铁蛋白水平可作为器官功能障碍的有效早期指标。血清铁蛋白与PELOD-2评分之间存在正相关。铁蛋白升高与疾病预后较差之间存在关联。
