Chen Linlin, Deng Huidan, Cui Hengmin, Fang Jing, Zuo Zhicai, Deng Junliang, Li Yinglun, Wang Xun, Zhao Ling
College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. eCollection 2018 Jan 23.
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commonly the NF-κB, MAPK, and JAK-STAT pathways. Here, we review inflammatory responses within organs, focusing on the etiology of inflammation, inflammatory response mechanisms, resolution of inflammation, and organ-specific inflammatory responses.
炎症是免疫系统的一种生物学反应，可由多种因素触发，包括病原体、受损细胞和有毒化合物。这些因素可能在心脏、胰腺、肝脏、肾脏、肺、脑、肠道和生殖系统中引发急性和/或慢性炎症反应，潜在地导致组织损伤或疾病。传染性和非传染性病原体以及细胞损伤均可激活炎症细胞并触发炎症信号通路，最常见的是NF-κB、MAPK和JAK-STAT通路。在此，我们综述各器官内的炎症反应，重点关注炎症的病因、炎症反应机制、炎症的消退以及器官特异性炎症反应。
