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帕博利珠单抗治疗患者出现药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）的非典型表现：一例报告

Atypical Presentation of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) in a Patient on Pembrolizumab: A Case Report.

作者信息

Tran Hillary, Bhatt Geetika

机构信息

Anesthesiology, Lake Erie College of Osteopathic Medicine, Jacksonville, USA.

Hematology and Medical Oncology, Baptist Health-Jacksonville, Jacksonville, USA.

出版信息

Cureus. 2024 May 7;16(5):e59804. doi: 10.7759/cureus.59804. eCollection 2024 May.

DOI:10.7759/cureus.59804
PMID:38846231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11155428/
Abstract

Pembrolizumab is an immune checkpoint inhibitor that has been associated with numerous immune-mediated adverse effects. Several of these cutaneous side effects may include bullous pemphigoid, Stevens-Johnson syndrome, and drug reaction with eosinophilia and systemic symptoms (DRESS). Other case reports have reported DRESS as a rare side effect of immune checkpoint inhibitors but due to its variable presentation and similarities with other cutaneous diseases, it has proven to be a diagnostic challenge. In addition, no effective methods have been developed to monitor for such adverse skin reactions in patients on immunotherapy. Here, we report a diagnostic challenging case of pembrolizumab-induced blistering lesions that were initially treated as suspected Herpes zoster and/or bullous pemphigoid but further pathology was consistent with DRESS.

摘要

帕博利珠单抗是一种免疫检查点抑制剂，与多种免疫介导的不良反应相关。其中一些皮肤副作用可能包括大疱性类天疱疮、史蒂文斯-约翰逊综合征以及伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）。其他病例报告将DRESS报道为免疫检查点抑制剂的一种罕见副作用，但由于其表现多样且与其他皮肤病相似，已证明它是一个诊断难题。此外，尚未开发出有效的方法来监测接受免疫治疗患者的此类皮肤不良反应。在此，我们报告一例具有诊断挑战性的病例，该病例为帕博利珠单抗诱导的水疱性皮损，最初被当作疑似带状疱疹和/或大疱性类天疱疮进行治疗，但进一步的病理检查结果与DRESS一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/723f7ff30f0f/cureus-0016-00000059804-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/87069051f71d/cureus-0016-00000059804-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/c5ea2eefe899/cureus-0016-00000059804-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/723f7ff30f0f/cureus-0016-00000059804-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/87069051f71d/cureus-0016-00000059804-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/c5ea2eefe899/cureus-0016-00000059804-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f753/11155428/723f7ff30f0f/cureus-0016-00000059804-i03.jpg

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本文引用的文献

1
High Grade Dermatologic Adverse Events Associated With Immune Checkpoint Blockade for Cancer.与癌症免疫检查点阻断相关的高级别皮肤不良事件。
Front Med (Lausanne). 2022 Jun 13;9:898790. doi: 10.3389/fmed.2022.898790. eCollection 2022.
2
Prognostic implications of co-occurring dermatologic and gastrointestinal toxicity from immune checkpoint inhibition therapy for advanced malignancies: A retrospective cohort study.免疫检查点抑制疗法治疗晚期恶性肿瘤时并发皮肤和胃肠道毒性的预后意义：一项回顾性队列研究。
J Am Acad Dermatol. 2020 Mar;82(3):743-746. doi: 10.1016/j.jaad.2019.07.049. Epub 2019 Jul 23.
3
Case Reports of DRESS Syndrome and Symptoms Consistent with DRESS Syndrome Following Treatment with Recently Marketed Monoclonal Antibodies.
药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征病例报告以及使用近期上市的单克隆抗体治疗后出现的符合DRESS综合征的症状
Autoimmune Dis. 2019 Jun 9;2019:7595706. doi: 10.1155/2019/7595706. eCollection 2019.
4
Pembrolizumab-induced bullous pemphigoid.帕博利珠单抗诱发的大疱性类天疱疮。
JAAD Case Rep. 2019 Apr 5;5(4):362-364. doi: 10.1016/j.jdcr.2019.02.008. eCollection 2019 Apr.
5
Drug Reaction with Eosinophilia and Systemic Symptoms: An Update and Review of Recent Literature.药物超敏反应伴嗜酸性粒细胞增多和全身症状：近期文献综述与更新
Indian J Dermatol. 2018 Jan-Feb;63(1):30-40. doi: 10.4103/ijd.IJD_582_17.
6
Herpes zoster in patients with bullous pemphigoid: a population-based case-control and cohort study.大疱性类天疱疮患者的带状疱疹：一项基于人群的病例对照和队列研究。
Br J Dermatol. 2016 May;174(5):1112-4. doi: 10.1111/bjd.14321. Epub 2016 Feb 4.
7
Immune Checkpoint Blockade in Cancer Therapy.癌症治疗中的免疫检查点阻断疗法
J Clin Oncol. 2015 Jun 10;33(17):1974-82. doi: 10.1200/JCO.2014.59.4358. Epub 2015 Jan 20.
8
Bullous pemphigoid after herpes zoster vaccine administration: association or coincidence?接种带状疱疹疫苗后发生大疱性类天疱疮：关联还是巧合？
J Drugs Dermatol. 2011 Nov;10(11):1328-30.