埃塞俄比亚西北部综合专科医院孕妇妊娠剧吐的患病率及其相关因素：多中心横断面研究
Prevalence of hyperemesis gravidarum and associated factors among pregnant women at comprehensive specialized hospitals in northwest Ethiopia: Multicenter cross-sectional study.
作者信息
Mohammed Seid Abdulwase, Mehari Eden Abetu, Bekalu Abaynesh Fentahun, Dula Sema Faisel, Limenh Liknaw Workie, Geremew Derso Teju, Tessema Tewodros Ayalew, Anagaw Yeniewa Kerie, Mitku Melese Legesse, Worku Minichil Chanie, Bizuneh Gizachew Kassahun, Ayenew Wondim, Simegn Wudneh
机构信息
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
SAGE Open Med. 2024 Jun 5;12:20503121241257163. doi: 10.1177/20503121241257163. eCollection 2024.
BACKGROUND
Hyperemesis gravidarum is one of the problems encountered among pregnant women due to persistent and excessive vomiting starting before the end of the 22nd week of gestation. The current study aimed to assess the prevalence of hyperemesis gravidarum and associated factors among pregnant women at comprehensive specialized hospitals in northwest Ethiopia.
METHODS
A multi-facility-based cross-sectional study was conducted at comprehensive specialized hospitals from 1st June 2022 to 30th July 2022. The data were entered using EPI Data Version 4.6 statistical software and analyzed using SPSS Version 26. Descriptive statistics such as frequency, mean, and percentage were calculated. Univariable and multivariable binary logistic regression analyses were carried out to identify the associated factors of hyperemesis gravidarum.
RESULTS
In all, 404 study participants were enrolled. About 16.8% of pregnant women were found to have hyperemesis gravidarum. Age < 20 year (AOR = 3.170; 95% CI: 1.119, 8.980), study participants who cannot read and write (AOR = 5.662; 95% CI: 2.036, 15.7470), grade 1-8 (AOR = 4.679; 95% CI: 1.778, 12.316), and grade 9-10 (AOR = 8.594; 95% CI: 3.017, 24.481), being housewife (AOR = 6.275; 95% CI: 1.052, 37.442), living in urban area (AOR = 2.185; 95% CI: 1.035, 4.609), having previous hyperemesis gravidarum (AOR = 2.463; 95% CI: 1.210, 5.012), having family history of hyperemesis gravidarum (AOR = 2.014; 95% CI: 1.002, 4.047), unplanned pregnancy (AOR = 2.934; 95% CI: 1.030, 8.351), having recent abortion (AOR = 2.750; 95% CI: 1.010, 7.483), and gravidity (AOR = 1.956; 95%CI: 1.023, 3.737) were factors associated with hyperemesis gravidarum.
CONCLUSION
The prevalence of hyperemesis gravidarum is higher. Low maternal age, lower educational level, being a housewife, being an urban resident, having previous hyperemesis gravidarum, having a family history, having an unplanned pregnancy, and having a recent abortion were significantly associated with hyperemesis gravidarum.
背景
妊娠剧吐是孕妇在妊娠22周结束前出现持续性过度呕吐所面临的问题之一。本研究旨在评估埃塞俄比亚西北部综合专科医院孕妇中妊娠剧吐的患病率及相关因素。
方法
于2022年6月1日至2022年7月30日在综合专科医院开展了一项基于多机构的横断面研究。数据使用EPI Data 4.6版统计软件录入，并使用SPSS 26版进行分析。计算了频率、均值和百分比等描述性统计量。进行单变量和多变量二元逻辑回归分析以确定妊娠剧吐的相关因素。
结果
共纳入404名研究参与者。约16.8%的孕妇被发现患有妊娠剧吐。年龄<20岁（调整后比值比[AOR]=3.170；95%置信区间[CI]：1.119，8.980）、不识字和不会写字的研究参与者（AOR=5.662；95%CI：2.036，15.7470）小学1-8年级（AOR=4.679；95%CI：1.778，12.316）、9-10年级（AOR=8.594；95%CI：3.017，24.481）、家庭主妇（AOR=6.275；95%CI：1.052，37.442）、居住在城市地区（AOR=2.185；95%CI：1.035，4.609）、既往有妊娠剧吐史（AOR=2.463；95%CI：1.210，5.012）、有妊娠剧吐家族史（AOR=2.014；95%CI：1.002，4.047）、意外怀孕（AOR=2.934；95%CI：1.030，8.351）、近期有流产史（AOR=2.750；95%CI：1.010，7.483）以及孕次（AOR=1.956；95%CI：1.023，3.737）是与妊娠剧吐相关的因素。
结论
妊娠剧吐的患病率较高。低孕产妇年龄、较低的教育水平、家庭主妇身份、城市居民身份、既往有妊娠剧吐史、有家族史、意外怀孕以及近期有流产史与妊娠剧吐显著相关。
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