Kalluru Pavan Kumar Reddy, Bhavanthi Sushmitha, Vashist Shambhavi, Gopavaram Ravikishore Reddy, Mamilla Mahesh, Sharma Shriya, Gundoji Chethan Raj, Goguri Sumaja Reddy
Sri Venkateswara Medical College, Puducherry.
General Medicine, Nizamabad Government Medical College, Nizamabad.
Ann Med Surg (Lond). 2024 May 1;86(6):3608-3614. doi: 10.1097/MS9.0000000000002113. eCollection 2024 Jun.
This review aims to explore the potential of erythropoietin, a glycopeptide hormone, as a treatment option for Alzheimer's disease, which is the commonest cause of dementia. Despite years of focus and research, therapeutic options for Alzheimer's disease are not yet completely satisfactory. And as people age, they are likely to develop Alzheimer's Disease, further pressuring the healthcare system. So, it is definite to develop treatment options that meet superior outcomes with minimal negative effects. A comprehensive review of the literature was conducted in PubMed and Google Scholar using a combination of keywords, including Alzheimer's disease, dementia, erythropoietin, and neuroprotection. Search results were assessed for relevance before using the data for this study. The beneficial implications of erythropoietin as a therapeutic option have been explored, along with the side effects and mechanisms of erythropoietin in Alzheimer's disease. Overall, the authors' review indicates that erythropoietin presents a promising avenue for mitigating the progression of Alzheimer's disease, with minimal associated side effects.
本综述旨在探讨糖蛋白激素促红细胞生成素作为治疗阿尔茨海默病(最常见的痴呆病因)的一种选择的潜力。尽管经过多年的关注和研究,阿尔茨海默病的治疗选择仍不尽人意。随着人们年龄的增长,他们很可能会患上阿尔茨海默病,这给医疗系统带来了更大压力。因此,开发出具有卓越疗效且副作用最小的治疗方案势在必行。我们在PubMed和谷歌学术上使用包括阿尔茨海默病、痴呆、促红细胞生成素和神经保护等关键词组合进行了全面的文献综述。在将搜索结果用于本研究之前,先对其相关性进行了评估。我们探讨了促红细胞生成素作为一种治疗选择的有益影响,以及促红细胞生成素在阿尔茨海默病中的副作用和作用机制。总体而言,作者的综述表明,促红细胞生成素为减缓阿尔茨海默病的进展提供了一条有前景的途径,且相关副作用极小。