Reshef E, Greenberg S B, Jankovic J
J Neurol Neurosurg Psychiatry. 1985 Feb;48(2):122-7. doi: 10.1136/jnnp.48.2.122.
Two patients with herpes zoster ophthalmicus and contralateral hemiparesis are described, and their findings compared with 49 patients previously reported. These patients presented with delayed contralateral hemiparesis approximately seven weeks after the onset of herpes zoster ophthalmicus. Most patients had evidence of infarction of the ipsilateral middle cerebral artery by angiography or by CT scan. Cerebrospinal fluid pleocytosis and elevated protein commonly were found. Twenty per cent of the reported patients died, but they were older than the patients who survived and predisposed to have diffuse CNS lesions. The pathogenesis of this syndrome is thought to be due to direct viral invasion of the blood vessel wall with resulting angiitis. Further studies need to be performed to clarify the role of specific antiviral therapy or anti-inflammatory agents in treating this complication of herpes zoster.
本文描述了两名患有眼带状疱疹并伴有对侧偏瘫的患者，并将他们的检查结果与之前报道的49名患者进行了比较。这些患者在眼带状疱疹发病约七周后出现延迟性对侧偏瘫。大多数患者通过血管造影或CT扫描显示同侧大脑中动脉梗死。脑脊液淋巴细胞增多和蛋白质升高很常见。据报道，20%的患者死亡，但他们的年龄比存活患者大，且易发生弥漫性中枢神经系统病变。该综合征的发病机制被认为是由于病毒直接侵袭血管壁导致血管炎。需要进一步研究以阐明特异性抗病毒治疗或抗炎药物在治疗眼带状疱疹这种并发症中的作用。
