Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Enghelab Street, Pich-E-Shemiran, Tehran, Iran.
Department of Communication Science & Disorders, University of Iowa, Iowa, USA.
Eur Arch Otorhinolaryngol. 2024 Oct;281(10):5033-5049. doi: 10.1007/s00405-024-08732-8. Epub 2024 Jun 7.
Numerous treatment modalities have been suggested for managing tinnitus. Tailor-Made Notched Music Training (TMNMT) is a viable strategy in music therapy for tinnitus management. Many research studies have examined the effectiveness and potential benefits of this intervention. This study aims to assess the effectiveness of TMNMT in treating chronic tinnitus.
This systematic review and meta-analysis study used a research methodology that covered up until February 2023. The search was conducted across academic databases including Google Scholar, PubMed, Scopus, and Web of Science. A total of 234 papers were evaluated, and seven relevant clinical trials were included.
The meta-analysis, which included five studies using the tinnitus handicap inventory (THI), showed no statistically significant effect of TMNMT on tinnitus handicap after 3 and 6 months of intervention (dppc2: - 0.99, 95%CI - 2.94 to 0.96; I2 = 79.96%, p = 0.00), (dppc2 - 1.81, 95%CI - 5.63 to 2.01; I2 = 79.96%, p = 0.00). However, four out of five studies using the total Visual Analogue Scale (VAS) or its subscale showed positive effects of TMNMT on chronic tinnitus. Unfortunately, there were not enough articles to conduct a meta-analysis on this outcome.
Although the meta-analysis did not show a statistically significant effect of TMNMT on tinnitus handicap, the large effect size observed after at least 3 months of intervention suggests that this method may potentially decrease tinnitus handicap if more studies are conducted. Due to the limited number of studies, subgroup analysis could not be performed to analyze potential causes of heterogeneity. Therefore, further high-quality clinical trials are necessary to draw a definitive conclusion and evaluate the impact of different variables, techniques, and outcomes.
有许多治疗方法被建议用于治疗耳鸣。定制凹口音乐训练(TMNMT)是耳鸣管理音乐治疗中的一种可行策略。许多研究已经研究了这种干预措施的有效性和潜在益处。本研究旨在评估 TMNMT 治疗慢性耳鸣的有效性。
本系统回顾和荟萃分析研究使用了一种研究方法,涵盖截至 2023 年 2 月的研究。研究在包括 Google Scholar、PubMed、Scopus 和 Web of Science 在内的学术数据库中进行了搜索。共评估了 234 篇论文,纳入了 7 项相关的临床试验。
荟萃分析包括五项使用耳鸣残疾量表(THI)的研究,结果显示 TMNMT 对干预后 3 个月和 6 个月的耳鸣残疾没有统计学上的显著影响(dppc2:-0.99,95%CI-2.94 至 0.96;I2=79.96%,p=0.00),(dppc2:-1.81,95%CI-5.63 至 2.01;I2=79.96%,p=0.00)。然而,五项使用总视觉模拟量表(VAS)或其分量表的研究中有四项显示 TMNMT 对慢性耳鸣有积极影响。不幸的是,没有足够的文章可以对此结果进行荟萃分析。
尽管荟萃分析显示 TMNMT 对耳鸣残疾没有统计学上的显著影响,但至少 3 个月干预后的大效应量表明,如果进行更多的研究,这种方法可能会潜在地降低耳鸣残疾。由于研究数量有限,无法进行亚组分析来分析异质性的潜在原因。因此,需要进一步进行高质量的临床试验,以得出明确的结论,并评估不同变量、技术和结果的影响。