Alfonso Scarpa, Mario Carucci, Pietro De Luca, Salzano Giovanni, Pasquale Viola, Claudia Cassandro, Giuseppe Chiarella, Maria Gioacchini Federico, Filippo Ricciardiello, Emilio Avallone, Antonio Salzano Francesco
Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
Department of Otolaryngology, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Am J Otolaryngol. 2024 Nov-Dec;45(6):104467. doi: 10.1016/j.amjoto.2024.104467. Epub 2024 Aug 3.
We systematically reviewed and meta-analyzed the efficacy of Tailor-Made Notched Music Training (TMNMT) for primary subjective tinnitus in adults. The main goal was to evaluate TMNMT's impact on tinnitus symptoms.
Following PRISMA guidelines, we included randomized and non-randomized trials. Studies considered involved adults with primary subjective tinnitus treated with TMNMT alone or combined with other therapies. Bias risk was assessed using the Cochrane RoB 2 and ROBINS-I tools. Comprehensive database searches were conducted, and relevant data were extracted and analyzed.
Three studies (total: 99 TMNMT patients, 109 sound therapy) were meta-analyzed. Using THI scores, the Forest plot showed no significant difference in tinnitus distress between TMNMT and listening to music groups (p > 0.05), with low study heterogeneity (I2 = 0 %).
While TMNMT offers a non-invasive approach with a potential to reduce tinnitus distress, it did not significantly outperform the only listening to music. More research is needed to optimize TMNMT for tinnitus management and to better document its safety profile.
我们系统回顾并荟萃分析了量身定制的缺口音乐训练（TMNMT）对成人原发性主观性耳鸣的疗效。主要目标是评估TMNMT对耳鸣症状的影响。
遵循PRISMA指南，我们纳入了随机和非随机试验。纳入的研究涉及单独使用TMNMT或与其他疗法联合治疗的原发性主观性耳鸣成人患者。使用Cochrane RoB 2和ROBINS-I工具评估偏倚风险。进行了全面的数据库检索，并提取和分析了相关数据。
对三项研究（共99例TMNMT患者，109例声音疗法患者）进行了荟萃分析。使用THI评分，森林图显示TMNMT组和听音乐组之间在耳鸣困扰方面无显著差异（p>0.05），研究异质性较低（I2 = 0%）。
虽然TMNMT提供了一种非侵入性方法，有可能减轻耳鸣困扰，但它并没有显著优于单纯听音乐。需要更多研究来优化TMNMT用于耳鸣管理，并更好地记录其安全性。
