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几个关于使用与遗传编码相关的例子的扩展 Petri 网的应用范畴论状态的补充概念:迈向分子/遗传生物学的抽象代数公式。

Several supplementary concepts for applied category-theoretical states over an extended Petri net using an example relating to genetic coding: Toward an abstract algebraic formulation of molecular/genetic biology.

机构信息

Nishigahara Hospital, Tokyo, Japan.

Depression Prevention Medical Center, Inariyama Takeda Hospital, Kyoto, Japan.

出版信息

PLoS One. 2024 Jun 7;19(6):e0302710. doi: 10.1371/journal.pone.0302710. eCollection 2024.

Abstract

algebraic concepts such as category are considered cornerstones on which logical consistency relies in any sophisticated study of natural phenomena. However, to the best of our knowledge, in molecular/genetic biology, their application is still severely limited because they capture neither the dynamics nor provide a visual form. The Petri net (PN) has often been used to illustrate visually parallel, asynchronous dynamic events in small data systems. A prototypal hybrid model combining both category theory and extended PNs may instead be indispensable for that purpose. This hybrid model incorporates 1) token-like elements of a group, 2) object-like places of a category, 3) square poles (rather than pentagon poles) that enable unique identifications of single-strand DNA sequences from the shape of its polygonal line, 4) creation/annihilation morphisms that generate/erase tokens, 5) Cartesian products 'Z5×Z2×…' that enable conversions between DNA and RNA sequences, 6) somatic recombinations (VDJ recombinations) for antibodies displayed concretely in category-theoretic form, 7) 'identity protein Δ' translated from a triplet of identity bases 'EEE' as an advanced concept from our previous display of the canonical central dogma, 8) illustrations of an incidence-matrix-like matrix A that includes operators as coordinates, and 9) basic topics concerning the canonical central dogma being displayed concretely using concepts of conventional category theory such as 'adjoint', 'adjoint functor', 'natural transformation', 'Yoneda's lemma' and 'Kan extension'. These ideas provide more advanced tools that expand our previous model concerning nucleic-acid-base sequences. Despite the nascent nature of our methodology, our hybrid model has potential in a variety of applications, illustrated using molecular/genetic sequences, in particular providing a simple dynamic/visual representation. With further improvements, this approach may prove effective in reducing the need for large data-storing systems.

摘要

代数概念,如范畴,被认为是逻辑一致性的基石,是任何对自然现象进行复杂研究的基础。然而,就我们所知,在分子/遗传学中,它们的应用仍然受到严重限制,因为它们既不能捕捉动态,也不能提供可视化形式。Petri 网 (PN) 常用于直观地表示小数据系统中的并行、异步动态事件。原型混合模型结合范畴理论和扩展的 PN 可能是必不可少的。该混合模型结合了以下元素:1)群的类似标记的元素,2)范畴的类似对象的位置,3)正方形极点(而不是五边形极点),可以根据多边形线的形状唯一识别单链 DNA 序列,4)创建/消除形态,生成/删除标记,5)笛卡尔积 'Z5×Z2×...',允许在 DNA 和 RNA 序列之间进行转换,6)体细胞重组(VDJ 重组),以范畴理论形式具体展示抗体,7)从三联体身份碱基 'EEE' 翻译而来的身份蛋白 Δ,作为我们之前展示规范中心法则的高级概念,8)矩阵 A 的关联矩阵样表示,其中包括作为坐标的算子,9)使用传统范畴理论的具体概念,如 '伴随'、'伴随函子'、'自然变换'、'Yoneda 引理' 和 'Kan 扩张',展示规范中心法则的基本主题。这些想法提供了更高级的工具,可以扩展我们之前关于核酸碱基序列的模型。尽管我们的方法尚处于起步阶段,但我们的混合模型在各种应用中具有潜力,特别是在分子/遗传学序列中,提供了简单的动态/可视化表示。通过进一步改进,这种方法可能有助于减少对大型数据存储系统的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/097f/11161097/2a52b509a7e0/pone.0302710.g001.jpg

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