The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
PLoS One. 2024 Jun 7;19(6):e0301859. doi: 10.1371/journal.pone.0301859. eCollection 2024.
The purpose of this study is to investigate the relationship between single nucleotide polymorphisms of inflammatory cytokines and neonatal sepsis through meta-analysis.
We collected research literature on the correlation between inflammatory cytokine polymorphisms and neonatal sepsis published before August 2023 through computer searches of databases such as PubMed, Embase, etc. The Stata 14.0 software was utilized for Meta-analysis. To assess heterogeneity, the chi-squared Q-test and I2 statistics were used. The Egger and Begg tests were conducted to determine the possibility of publication bias.
After reviewing 1129 articles, 29 relevant articles involving 3348 cases and 5183 controls were included in the study. The meta-analysis conducted on IL-1βrs1143643 polymorphism revealed significant findings: the T allele genotype has a lower risk of neonatal sepsis(P = 0.000, OR = 0.224, 95% CI: 0.168-0.299), while the TC and TT genotypes showed an increased risk(TC: P = 0.000,OR = 4.251, 95% CI: 2.226-8.119; TT: P = 0.019,OR = 2.020, 95% CI: 1.122-3.639). Similarly, newborns with the IL-6-174 CC genotype had a significantly higher risk of sepsis(P = 0.000,OR = 1.591, 95% CI: 1.154-2.194), while those with the IL-8-rs4073 TT (P = 0.003,OR = 0.467, 95% CI: 0.280-0.777)and TT + AA(P = 0.003,OR = 0.497, 95% CI: 0.315-0.785) genotypes had a significantly lower risk of sepsis. For the IL-10-1082 gene, newborns with the AA genotype(P = 0.002,OR = 1.702, 95% CI: 1.218-2.377), as well as those with the AA + GA genotype(P = 0.016,OR = 1.731, 95% CI: 1.108-2.705), had a significantly higher risk of sepsis. Lastly, newborns carrying the TNF-α-308 A allele (P = 0.016,OR = 1.257, 95% CI: 1.044-1.513)or the AA genotype(P = 0.009,OR = 1.913, 95% CI: 1.179-3.10) have a significantly increased risk of sepsis. Notwithstanding, additional studies must be included for validation. Applying these cytokines in clinical practice and integrating them into auxiliary examinations facilitates the early detection of susceptible populations for neonatal sepsis, thereby providing a new diagnostic and therapeutic approach for neonatal sepsis.
通过荟萃分析研究炎症细胞因子单核苷酸多态性与新生儿败血症的关系。
计算机检索 PubMed、Embase 等数据库，收集截至 2023 年 8 月前发表的关于炎症细胞因子多态性与新生儿败血症相关性的相关研究文献。采用 Stata14.0 软件进行 Meta 分析。采用卡方 Q 检验和 I 2 统计量评估异质性，采用 Egger 和 Begg 检验评估发表偏倚的可能性。
共检索到 1129 篇文献，纳入 29 篇符合标准的文献，共计 3348 例病例和 5183 例对照。对白细胞介素-1βrs1143643 多态性的 Meta 分析结果显示，T 等位基因基因型患新生儿败血症的风险较低（P=0.000，OR=0.224，95%CI：0.168-0.299），而 TC 和 TT 基因型患新生儿败血症的风险增加（TC：P=0.000，OR=4.251，95%CI：2.226-8.119；TT：P=0.019，OR=2.020，95%CI：1.122-3.639）。同样，白细胞介素-6-174CC 基因型的新生儿患败血症的风险显著增加（P=0.000，OR=1.591，95%CI：1.154-2.194），而白细胞介素-8-rs4073 TT（P=0.003，OR=0.467，95%CI：0.280-0.777）和 TT+AA（P=0.003，OR=0.497，95%CI：0.315-0.785）基因型的新生儿患败血症的风险显著降低。对于白细胞介素-10-1082 基因，AA 基因型的新生儿（P=0.002，OR=1.702，95%CI：1.218-2.377）和 AA+GA 基因型的新生儿（P=0.016，OR=1.731，95%CI：1.108-2.705）患败血症的风险显著增加。最后，携带肿瘤坏死因子-α-308A 等位基因（P=0.016，OR=1.257，95%CI：1.044-1.513）或 AA 基因型（P=0.009，OR=1.913，95%CI：1.179-3.10）的新生儿患败血症的风险显著增加。但仍需要更多的研究进行验证。将这些细胞因子应用于临床实践，并将其纳入辅助检查中，有助于早期发现易患新生儿败血症的人群，为新生儿败血症提供新的诊断和治疗方法。
