重新定义肠道干细胞：新的 ISC 群体的出现。

Redefining intestinal stemness: The emergence of a new ISC population.

机构信息

Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.

Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA.

出版信息

Cell. 2024 Jun 6;187(12):2900-2902. doi: 10.1016/j.cell.2024.04.021.

DOI:10.1016/j.cell.2024.04.021

PMID:38848673

Abstract

In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al. and Malagola, Vasciaveo, et al. identify a new ISC population in the upper crypt that can generate Lgr5 stem cells during homeostasis.

摘要

在组织稳态中，肠道干细胞（ISCs）通过持续的自我更新来维持快速的细胞更替。在本期《细胞》杂志上，Capdevila 等人和 Malagola、Vasciaveo 等人发现，在上皮隐窝中有一个新的 ISC 群体，它可以在稳态下产生 Lgr5 干细胞。