Brater D C, Anderson S, Baird B, Campbell W B
Kidney Int. 1985 Jan;27(1):66-73. doi: 10.1038/ki.1985.11.
In contrast to other nonsteroidal anti-inflammatory drugs (NSAIDs), sulindac has been reported to inhibit systemic prostaglandins (PGs) while not affecting renal PGs. We studied 11 normal volunteers who received placebo, ibuprofen, naproxen, or sulindac in a randomized, double-blind fashion. After control periods assessing the effect of the NSAIDs alone, 40 mg of furosemide were administered. Overall, each of the drugs appeared similar. Renal function, plasma renin activity (PRA) and urinary PGs were not affected during control collections, while all three NSAIDs decreased thromboxane B2 (TxB2). After furosemide, all NSAIDs decreased fractional excretions of Na+ and Cl-, PRA, and TxB2 by equivalent degrees (P less than 0.05). Sulindac and ibuprofen decreased urinary PGE2 (P less than 0.05) while naproxen had no effect. None of these drugs affected the excretion of furosemide, but all decreased the pharmacodynamics of response to furosemide. In conclusion, the effects of these NSAIDs depended on the conditions of the study. In the basal state there were no renal effects but all decreased the renal response to furosemide.
与其他非甾体抗炎药（NSAIDs）不同，据报道舒林酸可抑制全身前列腺素（PGs），而不影响肾脏PGs。我们以随机、双盲方式研究了11名接受安慰剂、布洛芬、萘普生或舒林酸的正常志愿者。在评估单独使用NSAIDs效果的对照期后，给予40mg呋塞米。总体而言，每种药物的表现相似。在对照期收集样本期间，肾功能、血浆肾素活性（PRA）和尿PGs均未受影响，而所有三种NSAIDs均降低了血栓素B2（TxB2）。给予呋塞米后，所有NSAIDs均使Na+和Cl-的分数排泄、PRA和TxB2降低程度相当（P<0.05）。舒林酸和布洛芬降低了尿PGE2（P<0.05），而萘普生无此作用。这些药物均未影响呋塞米的排泄，但均降低了对呋塞米反应的药效学。总之，这些NSAIDs的作用取决于研究条件。在基础状态下，它们对肾脏无影响，但均降低了肾脏对呋塞米的反应。
