• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Why is target trial emulation not being used in health technology assessment real-world data submissions?

作者信息

Castanon Alejandra, Duffield Stephen, Ramagopalan Sreeram, Reynolds Robert

机构信息

Lane Clark & Peacock LLP, London, W1U 1DQ, UK.

National Institute of Health & Care Excellence, Manchester, M1 4BT, UK.

出版信息

J Comp Eff Res. 2024 Aug;13(8):e240091. doi: 10.57264/cer-2024-0091. Epub 2024 Jun 8.

DOI:10.57264/cer-2024-0091
PMID:38850128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11284816/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9940/11284816/97e7b9f7eca4/cer-13-240091-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9940/11284816/97e7b9f7eca4/cer-13-240091-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9940/11284816/97e7b9f7eca4/cer-13-240091-g1.jpg

相似文献

1
Why is target trial emulation not being used in health technology assessment real-world data submissions?为什么目标试验模拟未被用于卫生技术评估的真实世界数据提交中？
J Comp Eff Res. 2024 Aug;13(8):e240091. doi: 10.57264/cer-2024-0091. Epub 2024 Jun 8.
2
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 15.我们准备好申请报销了吗？健康技术评估相关真实世界证据的发展综述：第15部分。
J Comp Eff Res. 2024 May;13(5):e240033. doi: 10.57264/cer-2024-0033. Epub 2024 Mar 28.
3
Introduction to target trial emulation in rehabilitation: a systematic approach to emulate a randomized controlled trial using observational data.康复中的目标试验模拟简介：使用观察数据模拟随机对照试验的系统方法。
Eur J Phys Rehabil Med. 2024 Feb;60(1):145-153. doi: 10.23736/S1973-9087.24.08435-1.
4
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 7.我们是否已准备好进行报销？与健康技术评估相关的真实世界证据的最新进展：第 7 部分。
J Comp Eff Res. 2022 Jul;11(10):699-701. doi: 10.2217/cer-2022-0071. Epub 2022 May 4.
5
Comparative effectiveness: beyond the buzz.
J Med Econ. 2012;15(6):1036-8. doi: 10.3111/13696998.2012.739841.
6
Target Trial Emulation for Transparent and Robust Estimation of Treatment Effects for Health Technology Assessment Using Real-World Data: Opportunities and Challenges.利用真实世界数据进行透明、稳健的卫生技术评估治疗效果的目标试验模拟：机遇与挑战。
Pharmacoeconomics. 2022 Jun;40(6):577-586. doi: 10.1007/s40273-022-01141-x. Epub 2022 Mar 25.
7
The Role of Noncomparative Evidence in Health Technology Assessment Decisions.非对比性证据在卫生技术评估决策中的作用。
Value Health. 2017 Dec;20(10):1245-1251. doi: 10.1016/j.jval.2017.06.015. Epub 2017 Sep 12.
8
Improving rheumatoid arthritis comparative effectiveness research through causal inference principles: systematic review using a target trial emulation framework.通过因果推理原则提高类风湿关节炎的比较疗效研究：基于目标试验模拟框架的系统评价。
Ann Rheum Dis. 2020 Jul;79(7):883-890. doi: 10.1136/annrheumdis-2020-217200. Epub 2020 May 7.
9
Use of External Comparators for Health Technology Assessment Submissions Based on Single-Arm Trials.基于单臂试验的卫生技术评估提交中使用外部对照。
Value Health. 2021 Aug;24(8):1118-1125. doi: 10.1016/j.jval.2021.01.015. Epub 2021 Jun 8.
10
Challenges and Opportunities in Interdisciplinary Research and Real-World Data for Treatment Sequences in Health Technology Assessments.在健康技术评估的治疗序列中，跨学科研究和真实世界数据面临的挑战与机遇。
Pharmacoeconomics. 2024 May;42(5):487-506. doi: 10.1007/s40273-024-01363-1. Epub 2024 Apr 1.

引用本文的文献

1
FRAME: Framework for Real-World Evidence Assessment to Mitigate Evidence Uncertainties for Efficacy/Effectiveness - An Evaluation of Regulatory and Health Technology Assessment Decision Making.框架：减轻疗效/有效性证据不确定性的真实世界证据评估框架——对监管和卫生技术评估决策的评估
Clin Pharmacol Ther. 2025 Sep;118(3):649-661. doi: 10.1002/cpt.3713. Epub 2025 Jun 10.
2
Strengthening health technology assessment for cancer treatments in Europe by integrating causal inference and target trial emulation.通过整合因果推断和目标试验模拟来加强欧洲癌症治疗的卫生技术评估。
Lancet Reg Health Eur. 2025 Apr 9;52:101294. doi: 10.1016/j.lanepe.2025.101294. eCollection 2025 May.
3

本文引用的文献

1
The estimands framework: a primer on the ICH E9(R1) addendum.估计量框架：ICH E9(R1)增编入门指南。
BMJ. 2024 Jan 23;384:e076316. doi: 10.1136/bmj-2023-076316.
2
Development of the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline.TRAnsPARENT Reporting of observational studies Emulating a Target trial (TARGET) 指南的制定。
BMJ Open. 2023 Sep 12;13(9):e074626. doi: 10.1136/bmjopen-2023-074626.
3
Evaluating Metformin Strategies for Cancer Prevention: A Target Trial Emulation Using Electronic Health Records.
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 18.
我们准备好申请报销了吗？与卫生技术评估相关的真实世界证据进展综述：第18部分。
J Comp Eff Res. 2025 Apr;14(4):e250014. doi: 10.57264/cer-2025-0014. Epub 2025 Feb 18.
4
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 17.我们准备好申请报销了吗？与卫生技术评估相关的真实世界证据进展综述：第17部分。
J Comp Eff Res. 2025 Jan;14(1):e240212. doi: 10.57264/cer-2024-0212. Epub 2024 Nov 27.
5
RWE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 16.真实世界研究是否已准备好报销？与卫生技术评估相关的真实世界证据发展综述：第 16 部分。
J Comp Eff Res. 2024 Aug;13(8):e240095. doi: 10.57264/cer-2024-0095. Epub 2024 Jul 5.
评估二甲双胍在癌症预防中的策略：基于电子健康记录的目标试验模拟。
Epidemiology. 2023 Sep 1;34(5):690-699. doi: 10.1097/EDE.0000000000001626. Epub 2023 May 23.
4
Emulating Target Trials With Real-World Data to Inform Health Technology Assessment: Findings and Lessons From an Application to Emergency Surgery.基于真实世界数据模拟目标试验以辅助卫生技术评估：一项应用于急诊手术的研究结果与经验教训。
Value Health. 2023 Aug;26(8):1164-1174. doi: 10.1016/j.jval.2023.04.010. Epub 2023 May 8.
5
A Structured Process to Identify Fit-for-Purpose Study Design and Data to Generate Valid and Transparent Real-World Evidence for Regulatory Uses.一种用于识别适合目的的研究设计和数据的结构化流程，以生成用于监管用途的有效和透明的真实世界证据。
Clin Pharmacol Ther. 2023 Jun;113(6):1235-1239. doi: 10.1002/cpt.2883. Epub 2023 Mar 17.
6
Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health.在确保进行相关卫生技术评估的同时，快速获取创新药品。法国国家卫生管理局的立场。
BMJ Evid Based Med. 2024 Jan 19;29(1):1-5. doi: 10.1136/bmjebm-2022-112091.
7
HARmonized Protocol Template to Enhance Reproducibility of Hypothesis Evaluating Real-World Evidence Studies on Treatment Effects: A Good Practices Report of a Joint ISPE/ISPOR Task Force.协调一致的方案模板，以提高评估治疗效果的真实世界证据研究假设再现性：国际药物经济学与结果研究学会/国际真实世界证据协会联合工作组的良好实践报告。
Value Health. 2022 Oct;25(10):1663-1672. doi: 10.1016/j.jval.2022.09.001.
8
The (Harsh) Reality of Real-World Data External Comparators for Health Technology Assessment.卫生技术评估中真实世界数据外部对照的（严峻）现实
Value Health. 2022 Jul;25(7):1253-1256. doi: 10.1016/j.jval.2022.01.014. Epub 2022 Mar 4.
9
STaRT-RWE: structured template for planning and reporting on the implementation of real world evidence studies.STaRT-RWE：用于规划和报告真实世界证据研究实施情况的结构化模板。
BMJ. 2021 Jan 12;372:m4856. doi: 10.1136/bmj.m4856.
10
Avoidable flaws in observational analyses: an application to statins and cancer.避免观察性分析中的缺陷：他汀类药物与癌症的应用。
Nat Med. 2019 Oct;25(10):1601-1606. doi: 10.1038/s41591-019-0597-x. Epub 2019 Oct 7.