Herpertz B, Burdach S E, Rister M
Monatsschr Kinderheilkd. 1985 Feb;133(2):82-5.
The increased susceptibility to bacterial infections due to a decreased chemotaxis of neutrophil granulocytes was investigated in a premature small for gestational age baby, who such suffered from recurrent E. coli-meningitis. Causes as anatomic lesions, brain abscess, septic granuloumatosus disease and the Chédiak-Higashi-anomaly were ruled out. At the age of 9 and 13 weeks chemotaxis function compared to age-matched and adult controls was diminished. Addition of serum from healthy adults increased directed migration without reaching normal levels. The study of the complement status revealed a diminution of CH50, the alternate pathway components and C6-C9. Thus, decreased chemotaxis is believed to originate from a combined intrinsic-extrinsic defect. No relapses of infection were observed during prophylactic treatment with ascorbate and cotrimoxazole. Intrinsic as well as extrinsic chemotaxis became normal at the age of 7 months. Simultaneously, complement status was found to approach normal levels. The relevance of haematologic-immunologic evaluation in cases of relapsing severe bacterial infections in preterm newborns is discussed.
在一名早产低体重儿中，研究了由于中性粒细胞趋化性降低导致的对细菌感染易感性增加的情况，该患儿反复患大肠杆菌脑膜炎。排除了解剖学病变、脑脓肿、脓毒性肉芽肿病和切-东综合征等病因。在9周和13周龄时，与年龄匹配的对照和成人对照相比，趋化功能降低。添加健康成人的血清可增加定向迁移，但未达到正常水平。补体状态研究显示CH50、替代途径成分以及C6 - C9减少。因此，趋化性降低被认为源于内在 - 外在联合缺陷。在使用抗坏血酸和复方新诺明进行预防性治疗期间，未观察到感染复发。内在和外在趋化性在7个月龄时恢复正常。同时，补体状态接近正常水平。讨论了血液学 - 免疫学评估在早产新生儿复发性严重细菌感染病例中的相关性。
