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第二例人类C3b抑制剂(KAF)缺乏症。

A second case of human C3b inhibitor (KAF) deficiency.

作者信息

Thompson R A, Lachmann P J

出版信息

Clin Exp Immunol. 1977 Jan;27(1):23-9.

Abstract

The second case of C3b inhibitor deficiency is described in an 11-year-old girl who presented with recurrent attacks of meningitis, in between which she was well. Her serum showed all of the complement component changes noted in the first described case, although showing only a relatively slight defect in its ability to opsonize bacteria for phagocytosis and killing by polymorphonuclear leucocytes. This correlated with the patient's freedom from other infections.

摘要

第二例C3b抑制剂缺乏症发生在一名11岁女孩身上,她反复出现脑膜炎发作,发作间歇期情况良好。她的血清显示出首例所述病例中所有补体成分的变化,尽管在调理细菌以便被多形核白细胞吞噬和杀灭方面仅表现出相对轻微的缺陷。这与该患者未发生其他感染的情况相符。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94e/1540911/1a6ef5656f14/clinexpimmunol00239-0034-a.jpg

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