Tsuhako Kota, Sekido Katsuhisa, Ando Takumi, Okita Michiko, Harada Masashi, Hariya Yasushi
Department of Oral and Maxillofacial Surgery, Teine Keijinkai Hospital, 1-12-1-40, Maeda, Teine-ku, Sapporo city, Hokkaido 006-8555, Japan.
Department of Dentistry and Oral Surgery, Toyama Red Cross Hospital, 2-1-58, Ushijimahonnmachi, 930-0859 Toyama, Japan; Department of Oral and Maxillofacial Surgery, and Comprehensive Oral Science, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama city, Toyama 930-0194, Japan.
Int J Surg Case Rep. 2024 Jul;120:109822. doi: 10.1016/j.ijscr.2024.109822. Epub 2024 May 31.
Surgical therapy is effective for medication-related osteonecrosis of the jaw. However, appropriate conservative treatment options are still important for cases in which surgery is contraindicated. We report a case of medication-related osteonecrosis of the jaw successfully treated conservatively for a pathological mandibular fracture.
An 84-year-old female patient presented to our department with a chief complaint of inadequate healing of an extraction tooth socket. She had been taking minodronic acid hydrate for approximately five years for osteoporosis. The clinical examination revealed erythema, diffuse swelling of the left mandibular angle, erythema of the buccal gingiva adjacent to the left mandibular first molar, and fistula formation. Although surgery was recommended, the patient declined to proceed. Therefore, a conservative treatment was initiated. A pathological fracture of the inferior mandibular margin was observed one month after the initial visit. Mouth opening was restricted for six months using a bandage. Two months after the pathological fracture, the inferior margin of the fracture was aligned. Five months later, the inferior margin continued. One year later, the bony union of the fracture was observed.
Conservative treatment and restricting mouth opening was effective in our case. Three years and seven months after the pathological fracture, no new sequestrum formation was observed, and the patient was doing well.
Conservative treatment can be effective for medication-related osteonecrosis of the jaw with severe cases.
手术治疗对于药物相关性颌骨坏死有效。然而,对于手术禁忌的病例,适当的保守治疗选择仍然很重要。我们报告一例药物相关性颌骨坏死经保守治疗成功治愈病理性下颌骨骨折的病例。
一名84岁女性患者因拔牙创愈合不佳为主诉前来我科就诊。她因骨质疏松服用阿仑膦酸水合物约五年。临床检查发现红斑、左下颌角弥漫性肿胀、左下颌第一磨牙颊侧牙龈红斑及瘘管形成。尽管建议手术,但患者拒绝进行。因此,开始进行保守治疗。初诊后一个月观察到下颌下缘病理性骨折。使用绷带限制开口六个月。病理性骨折两个月后,骨折下缘对齐。五个月后,下缘持续愈合。一年后,观察到骨折骨性愈合。
在我们的病例中,保守治疗和限制开口是有效的。病理性骨折三年零七个月后,未观察到新的死骨形成,患者情况良好。
保守治疗对于严重的药物相关性颌骨坏死可能有效。