Department, Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena MO, Italy.
Department of Childhood and Adult Medical and Surgical Sciences, Faculty of Medicine and Surgery of the University of Modena and Reggio Emilia, Modena MO, Italy.
Curr Probl Cardiol. 2024 Sep;49(9):102699. doi: 10.1016/j.cpcardiol.2024.102699. Epub 2024 Jun 7.
Cardiovascular diseases (CVD) is the major cause of mortality globally, with increasing evidence suggesting a link between periodontitis, and CVD. This study aims to explore the association between periodontitis and CVD, and the impact of periodontal therapy on cardiovascular health.
This review synthesized findings from preclinical and clinical studies, without publication year restrictions, examining periodontitis and CVD through various lenses. Scientific databases were inspected with keywords related to periodontitis and CVD.
The review identifies a substantial association between periodontitis and an increased risk of several CVD, supported by both epidemiological and interventional studies. Results suggest the complexity of the relationship, influenced by factors like the severity of periodontitis and the presence of other systemic conditions. Clinical data indicates that periodontal therapy, particularly non-surgical periodontal therapy, may reduce systemic inflammatory markers and thus may play a role in the primary and secondary prevention of CVD events, highlighting the potential of periodontal therapy to not only maintain oral health but also to modulate cardiovascular risk factors.
Current evidence supports a significant association between periodontitis and increased cardiovascular risk, promoting integrated healthcare approaches that consider oral health as a key-component of cardiovascular care and wellbeing.
心血管疾病（CVD）是全球主要的死亡原因，越来越多的证据表明牙周炎与 CVD 之间存在关联。本研究旨在探讨牙周炎与 CVD 之间的关系，以及牙周治疗对心血管健康的影响。
本综述综合了无发表年限限制的临床前和临床研究结果，从多个角度研究了牙周炎和 CVD。通过与牙周炎和 CVD 相关的关键词，对科学数据库进行了检查。
本综述确定了牙周炎与多种 CVD 风险增加之间存在实质性关联，这一关联得到了流行病学和干预研究的支持。结果表明，这种关系的复杂性受到牙周炎严重程度和其他全身状况等因素的影响。临床数据表明，牙周治疗，特别是非手术性牙周治疗，可能降低全身炎症标志物，从而可能在 CVD 事件的一级和二级预防中发挥作用，突出了牙周治疗不仅可以维持口腔健康，还可以调节心血管危险因素的潜力。
目前的证据支持牙周炎与心血管风险增加之间存在显著关联，这促进了综合医疗保健方法的发展，将口腔健康视为心血管保健和整体健康的关键组成部分。
