Hadlock F P, Irwin J F, Roecker E, Shah Y P, Deter R L, Rossavik I K
Radiology. 1985 May;155(2):469-72. doi: 10.1148/radiology.155.2.3885311.
Amniocentesis for determination of fetal lung maturity and ultrasonographic (US) evaluation of the biparietal diameter (BPD) and placental grade were performed simultaneously in 261 nondiabetic pregnant women. A BPD of at least 9.3 cm and a grade 3 placenta were evaluated as predictors of fetal lung maturity using amniotic fluid phospholipids as indicators of a mature lung profile. The ability of the sonographic parameters to predict fetal lung maturity was closely related to menstrual age. Before 37 weeks, the false-positive prediction rate using a grade 3 placenta was 100%, and the false-positive prediction using the BPD was 85.6%. After 37 weeks, the false-positive rate using a grade 3 placenta was 5.9%, and the false-positive rate using the BPD was 9.5%. Thus menstrual age, and not these two US parameters, dictated fetal lung maturity. The authors conclude that the best use of US for predicting fetal lung maturity is in establishing menstrual age early in pregnancy.
对261名非糖尿病孕妇同时进行了羊膜穿刺术以确定胎儿肺成熟度，并对双顶径（BPD）和胎盘分级进行了超声（US）评估。以羊水磷脂作为肺成熟度的指标，将至少9.3厘米的双顶径和3级胎盘评估为胎儿肺成熟度的预测指标。超声参数预测胎儿肺成熟度的能力与孕龄密切相关。在37周之前，使用3级胎盘的假阳性预测率为100%，使用双顶径的假阳性预测率为85.6%。37周之后，使用3级胎盘的假阳性率为5.9%，使用双顶径的假阳性率为9.5%。因此，是孕龄而非这两个超声参数决定胎儿肺成熟度。作者得出结论，超声预测胎儿肺成熟度的最佳用途是在妊娠早期确定孕龄。
