Mahmoud Yosra H, Eysa Basem, Ahmed Eman Mohamed Salah, Abdelaziz Heba, Zayed Ashgan Mohamed, Baki Amin Abdel, Hosny Ahmed, Hassany Mohamed
Department of Clinical Pathology, Gastrointerology and Infectious Diseases, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Department of Hepatology, Gastrointerology and Infectious Diseases, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Clin Exp Reprod Med. 2024 Dec;51(4):309-313. doi: 10.5653/cerm.2023.06772. Epub 2024 Jun 10.
Hepatitis C virus (HCV) infection is known to influence the seminal and hormonal parameters of infected men. This study was performed to assess the effects of HCV clearance using direct-acting antiviral (DAA) agents on semen and hormonal parameters.
A total of 50 patients with chronic HCV were enrolled, and conventional semen analysis was performed according to World Health Organization guidelines. Basal levels of total testosterone, free testosterone (FT), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin, and sex hormone-binding globulin (SHBG) were assessed before and 3 months after treatment with DAAs.
Following DAA treatment, statistically significant increases were observed in sperm motility and the proportion of grade A sperm. Additionally, the percentage of abnormal forms was significantly decreased after treatment (p=0.000). However, no significant differences were observed in semen volume, concentration, or total sperm count. Sex hormone analysis of patients after DAA treatment revealed significant increases in FT, LH, and FSH levels, along with significant decreases in SHBG, prolactin, and E2 levels.
Following HCV clearance, we noted an improvement in sperm motility and an increase in the percentage of sperm with normal morphology. Treatment with DAAs was also associated with increased levels of FT and LH, along with decreased levels of SHBG, prolactin, and E2.
已知丙型肝炎病毒（HCV）感染会影响受感染男性的精液和激素参数。本研究旨在评估使用直接抗病毒药物（DAA）清除HCV对精液和激素参数的影响。
共纳入50例慢性HCV患者，根据世界卫生组织指南进行常规精液分析。在使用DAA治疗前及治疗3个月后，评估总睾酮、游离睾酮（FT）、促卵泡激素（FSH）、促黄体生成素（LH）、雌二醇（E2）、催乳素和性激素结合球蛋白（SHBG）的基础水平。
DAA治疗后，精子活力和A级精子比例有统计学意义的显著增加。此外，治疗后异常形态的百分比显著降低（p=0.000）。然而，精液体积、浓度或总精子数未观察到显著差异。DAA治疗后患者的性激素分析显示，FT、LH和FSH水平显著升高，同时SHBG、催乳素和E2水平显著降低。
HCV清除后，我们注意到精子活力有所改善，正常形态精子的百分比增加。DAA治疗还与FT和LH水平升高以及SHBG、催乳素和E2水平降低有关。
