Antitumor aspochalasin and antiviral benzofuran derivatives from a marine-derived fungus sp. SCSIO41032.

Chemical investigation of the EtOAc extract of a deep-sea derived fungus sp. SCSIO41032 resulted in the isolation of ten known compounds, including eight aspochalasins. Their structures were elucidated by using extensive NMR spectroscopic, mass spectrometric and single crystal X-ray diffraction analysis. The detailed crystallographic data for structures , , and , along with the relative configurations of aspochalasin E () determined by its acetonide derivative were reported for the first time. The results of antitumor and antiviral activities showed that displayed moderate antitumor activities against 22Rv1, PC-3, A549, and HCT-15 cell lines with IC values ranged from 5.9 ± 0.8 to 19.0 ± 7.7 μM, and exhibited moderate antiviral activities against HSV-1/2 with EC values of 9.5 ± 0.5 and 5.4 ± 0.6 μM, respectively. Plate clone formation assays results indicated that inhibited the 22Rv1, PC-3 cells growth in a dose-dependent manner.