Stout Josephine, Dixit Naznin, Pasha Simeen, Sukumaran Anju, Topaloglu Ali Kemal, Armstrong Mary K, Garg Padma, Karlson Cynthia, Bates John T, Ansari Md Abu Yusuf, Kamran Fariha
Arkansas Children's Hospital, Little Rock, AR, USA.
University of Mississippi Medical Center, Jackson, MS, USA.
Ann Pediatr Endocrinol Metab. 2024 Aug;29(4):234-241. doi: 10.6065/apem.2346182.091. Epub 2024 Jun 5.
The coronavirus disease 2019 (COVID-19) pandemic has led to an association between COVID-19 and pediatric diabetes. Studies have indicated the increased likelihood of children with COVID-19 infection developing diabetes. Our objective was to assess not only the increase in pediatric diabetes at our hospital and identify possible risk factors, but also to correlate the psychosocial changes resulting from the pandemic with new-onset diabetes.
We analyzed data from 58 children aged 1 to 18 years admitted to our hospital with new-onset diabetes between March 2020 and December 2021. The data included inflammatory biomarkers and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies (Abs), as well as the results of a lifestyle questionnaire.
The average number of hospital admissions per month for new-onset diabetes increased from 10 to 18 with the start of the pandemic. Of the 58 children in our analysis, 33% had positive SARS-CoV-2 IgG Ab, 31% had type 1 diabetes mellitus, and 62% had type 2 diabetes mellitus (T2DM). More than half (54%) were experiencing diabetic ketoacidosis. Those with T2DM were older, majority African American, had higher median body mass index (BMI) percentiles, and lower vitamin D levels. There were no significant correlations between any psychosocial risk factors and either diabetes type or SARS-CoV2 Ab status.
Despite the increased incidence of new-onset diabetes among children in Mississippi during the pandemic, this study was unable to demonstrate a significant correlation between COVID-19 infection and new-onset diabetes. The findings of this study highlighted the correlation between increased BMI and type 2 diabetes, underscoring the significant problems of obesity and diabetes in our study region. Further research is warranted.
2019年冠状病毒病（COVID-19）大流行导致了COVID-19与儿童糖尿病之间的关联。研究表明，感染COVID-19的儿童患糖尿病的可能性增加。我们的目标不仅是评估我院儿童糖尿病的增加情况并确定可能的风险因素，还要将大流行导致的心理社会变化与新发糖尿病相关联。
我们分析了2020年3月至2021年12月期间我院收治的58例1至18岁新发糖尿病儿童的数据。数据包括炎症生物标志物和严重急性呼吸综合征冠状病毒2（SARS-CoV-2）抗体（Abs），以及生活方式问卷的结果。
随着大流行的开始，新发糖尿病每月的平均住院人数从10人增加到18人。在我们分析的58名儿童中，33%的SARS-CoV-2 IgG抗体呈阳性，其中31%患有1型糖尿病，62%患有2型糖尿病（T2DM）。超过一半（54%）的患儿出现糖尿病酮症酸中毒。患有T2DM的患儿年龄较大，大多数为非裔美国人，中位体重指数（BMI）百分位数较高，维生素D水平较低。任何心理社会风险因素与糖尿病类型或SARS-CoV2抗体状态之间均无显著相关性。
尽管在大流行期间密西西比州儿童新发糖尿病的发病率有所增加，但本研究未能证明COVID-19感染与新发糖尿病之间存在显著相关性。本研究结果突出了BMI增加与2型糖尿病之间的相关性，强调了我们研究地区肥胖和糖尿病的重大问题。有必要进行进一步的研究。
