Monti Martin M
Department of Psychology, University of California Los Angeles, 502 Portola Plaza, Los Angeles, 90095, CA, USA.
Brain Injury Research Center (BIRC), Department of Neurosurgery, University of California Los Angeles, 300 Stein Plaza Driveway, Los Angeles, 90095, CA, USA.
bioRxiv. 2025 Feb 17:2024.05.29.596530. doi: 10.1101/2024.05.29.596530.
To assess the association between self-reported measures of sleep quality and cortical and subcortical local morphometry.
Sleep quality, operationalized with the Pittsburgh Sleep Quality Index (PSQI), and neuroanatomical data from the full release of the young adult Human Connectome Project dataset were analyzed (N=1,112; 46% female; mean age: 28.8 years old). Local cortical and subcortical morphometry was measured with subject-specific segmentations resulting in voxelwise gray matter difference (i.e., voxel based morephometry) measurements for cortex and local shape measurements for subcortical regions. Associations between the total score of PSQI, two statistical groupings of its subcomponents (obtained with a principal component analysis), and their interaction with demographic (i.e., sex, age, handedness, years of education) and biometric (i.e., BMI) variables were assessed using a general linear model and a nonparametric permutation approach.
Sleep quality-related variance was significantly associated with subcortical morphometry, particularly in the bilateral caudate, putamen, and left pallidum, where smaller shape measures correlated with worse sleep quality. Notably, these associations were independent of demographic and biometric factors. In contrast, cortical morphometry, along with additional subcortical sites, showed no direct associations with sleep quality but demonstrated interactions with demographic and biometric variables.
This study reveals a specific link between self-reported sleep quality and subcortical morphometry, particularly within the striatum and pallidum, reinforcing the role of these regions in sleep regulation. These findings underscore the importance of considering subcortical morphology in sleep research and highlight potential neuromodulatory targets for sleep-related interventions.
评估自我报告的睡眠质量测量指标与皮质及皮质下局部形态学之间的关联。
分析了匹兹堡睡眠质量指数（PSQI）所衡量的睡眠质量，以及来自年轻成人人类连接组计划数据集完整版本的神经解剖学数据（N = 1112；46%为女性；平均年龄：28.8岁）。通过特定于个体的分割来测量局部皮质和皮质下形态学，从而得出皮质的体素级灰质差异（即基于体素的形态测量）测量值以及皮质下区域的局部形状测量值。使用一般线性模型和非参数置换方法评估PSQI总分、其亚成分的两种统计分组（通过主成分分析获得）及其与人口统计学（即性别、年龄、利手、受教育年限）和生物统计学（即BMI）变量的相互作用。
与睡眠质量相关的方差与皮质下形态学显著相关，特别是在双侧尾状核、壳核和左侧苍白球，其中较小的形状测量值与较差的睡眠质量相关。值得注意的是，这些关联独立于人口统计学和生物统计学因素。相比之下，皮质形态学以及其他皮质下部位与睡眠质量没有直接关联，但与人口统计学和生物统计学变量存在相互作用。
本研究揭示了自我报告的睡眠质量与皮质下形态学之间的特定联系，特别是在纹状体和苍白球内，强化了这些区域在睡眠调节中的作用。这些发现强调了在睡眠研究中考虑皮质下形态学的重要性，并突出了与睡眠相关干预措施的潜在神经调节靶点。
