Li Li, Liang Hui, Song Yifan, Zhang Zhaonan, An Jing, Li Ning, Sun Huifeng, Bao Ying, Mao Leijin, Ding Lin, Yan Jie, Wang Zhiguo, Cao Lei, Ye Jiakai, Yu Wenzhou
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing, China.
National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC Wkly. 2024 May 10;6(19):418-423. doi: 10.46234/ccdcw2024.083.
WHAT IS ALREADY KNOWN ON THIS TOPIC?: In China, there is limited data available on the use and coverage of the non-program, combined diphtheria, tetanus toxoid, acellular pertussis adsorbed, inactivated poliovirus and haemophilus influenzae type b (DTaP-IPV/Hib) pentavalent vaccine, and its role as a substitute for the separately administered standalone program vaccines.
WHAT IS ADDED BY THIS REPORT?: We evaluated the use and coverage of the pentavalent vaccine in nine provincial-level administrative divisions (PLADs) spanning eastern, central, and western China from 2019 to 2021. Initial use and coverage were low, but demonstrated annual growth albeit with regional and urban-rural discrepancies. The pentavalent vaccine was increasingly substituted for standalone vaccines over the course of this period.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Parents in China are increasingly opting to replace the standard program vaccines with voluntarily purchased combination vaccines, particularly the pentavalent vaccine. The development of combination vaccines should thus be promoted in China, as it could enhance utilization and coverage rates, and decrease the economic burden.
在中国，关于非计划内的白喉、破伤风类毒素、无细胞百日咳吸附、灭活脊髓灰质炎病毒和b型流感嗜血杆菌（DTaP-IPV/Hib）五价疫苗的使用和覆盖情况，以及其作为单独接种的计划内疫苗替代品的作用，可用数据有限。
我们评估了2019年至2021年期间中国东部、中部和西部九个省级行政区五价疫苗的使用和覆盖情况。最初的使用和覆盖率较低，但呈现出逐年增长的趋势，尽管存在地区和城乡差异。在此期间，五价疫苗越来越多地替代了单独的疫苗。
中国的家长越来越倾向于用自愿购买的联合疫苗替代标准计划内疫苗，尤其是五价疫苗。因此，中国应促进联合疫苗的研发，因为这可以提高利用率和覆盖率，并减轻经济负担。
