Heald A F, Ita C E, Singhvi S M, Migdalof B H
Xenobiotica. 1985 Jan;15(1):51-6. doi: 10.3109/00498258509045334.
35S-Captopril (50 mg/kg) administered i.v. to rats resulted in radioactivity being widely distributed into highly vascular tissues and into excretory organs. After oral administration of 14C-captopril (50 mg/kg), radioactivity in most tissues declined at a rate similar to that in blood. Concn. greater than those in blood were found only in kidney, liver and lung. The high concn. of 14C in kidney and liver were due to the excretory role of these organs. The high concn. of 14C in lung may be due to the high binding affinity of captopril to angiotensin-converting enzyme, present in large quantity in lung.
给大鼠静脉注射35S-卡托普利（50毫克/千克）后，放射性广泛分布于血管丰富的组织和排泄器官中。口服14C-卡托普利（50毫克/千克）后，大多数组织中的放射性以与血液中相似的速率下降。仅在肾脏、肝脏和肺中发现浓度高于血液中的浓度。肾脏和肝脏中14C的高浓度是由于这些器官的排泄作用。肺中14C的高浓度可能是由于卡托普利对肺中大量存在的血管紧张素转换酶具有高结合亲和力。
