Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Department of Chemistry, University of Washington-Seattle Campus, Seattle, WA, USA.
J Mater Chem B. 2024 Jun 19;12(24):5812-5822. doi: 10.1039/d4tb00659c.
Immunotherapy is an important approach in cancer treatment. Transdermal administration is emerging as a promising method for delivering immunotherapeutics. Dissolving microneedles are made mainly of soluble or biodegradable polymers and have garnered widespread attention due to their painlessness, safety, convenience, excellent drug loading capacity, and easy availability of various materials, making them an ideal transdermal delivery system. This review comprehensively summarized the preparation methods, materials, and applications of dissolving microneedles in cancer vaccines, immune checkpoint inhibitors, and adoptive cell therapy. Additionally, the challenges and perspectives associated with their future clinical translation are discussed.
免疫疗法是癌症治疗的重要方法。经皮给药作为一种有前途的免疫治疗药物传递方法正在兴起。溶解微针主要由可溶或可生物降解的聚合物制成，由于其无痛、安全、方便、载药能力优异以及易于获得各种材料，引起了广泛关注，是一种理想的经皮给药系统。本综述全面总结了溶解微针在癌症疫苗、免疫检查点抑制剂和过继细胞治疗中的制备方法、材料和应用。此外，还讨论了它们未来临床转化所面临的挑战和前景。
