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评价钾通道在血细胞增殖、迁移和侵袭中的作用。

Evaluation of the Role of Potassium Channels in the Proliferation, Migration, and Invasion of Blood Cells.

机构信息

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russian Federation.

出版信息

Methods Mol Biol. 2024;2796:185-190. doi: 10.1007/978-1-0716-3818-7_11.

Abstract

The potassium channels are one of the key regulators of cell membrane potential and permeability properties of blood cells. The changes in functioning of potassium channels control crucial cell processes such as proliferation, viability, migration, and invasion. The correct estimation of these processes is important for the characterization of physiological and pathophysiological cell states. Here, we present the experimental protocol for evaluation of the role of potassium ion channels in the proliferation, migration, and invasion of blood cells.

摘要

钾通道是细胞膜电位和血细胞通透性的关键调节因子之一。钾通道功能的变化控制着细胞的增殖、存活、迁移和侵袭等关键过程。正确评估这些过程对于描述生理和病理状态下的细胞状态非常重要。在这里,我们介绍了评估钾离子通道在血细胞增殖、迁移和侵袭中的作用的实验方案。

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