Department of Pediatrics, University of Turku, Turku, Finland.
Department of Pediatrics, Turku University Hospital, Turku, Finland.
Rheumatology (Oxford). 2024 Sep 1;63(9):2355-2362. doi: 10.1093/rheumatology/keae322.
Previous epidemiological data of JIA in Finland are from the turn of the millennium. We aimed to determine the recent annual incidence of JIA in several consecutive years in Finland and to explore the differences in incidence between sexes, age groups and regions.
We analysed all children <16 years of age who met the ILAR classification criteria for JIA. Cases from 2000-2020 were identified from two national registers: the Care Register for Health Care of the Finnish Institute for Health and Welfare and the Reimbursement Register containing medication data from the Social Insurance Institution of Finland; cases from 2016-2020 were identified from the Finnish Rheumatology Quality Register.
The incidence of JIA was 31.7 per 100 000 (95% CI 30.2, 33.1), according to the Care Register in 2000-2020 and peaked in 2010-2014. No considerable differences in incidence rates were observed among registers. In all age groups, incidence in girls was predominant compared with boys. The incidence in girls peaked at the ages of 2 years and 14-15 years. Decreasing incidence was observed among boys 0-3 years old during the entire study period, whereas increasing incidence was observed among teenage girls and boys 4-7 years old in 2000-2013.
The incidence of JIA is not only very high with respect to that in other parts of the world but also higher than previously reported in Finland. The incidence varied by region and year but was not higher at the end than the beginning of the study period.
芬兰之前有关幼年特发性关节炎（JIA）的流行病学数据来自千禧年之交。我们旨在确定芬兰在连续几年内 JIA 的近期年发病率，并探讨性别、年龄组和地区之间发病率的差异。
我们分析了符合国际风湿病联盟（ILAR）JIA 分类标准的所有<16 岁的儿童病例。2000-2020 年的病例来自两个国家登记处：芬兰卫生与福利研究所的医疗保健护理登记处和芬兰社会保险机构的药物数据补偿登记处；2016-2020 年的病例来自芬兰风湿病质量登记处。
根据 2000-2020 年的护理登记处，JIA 的发病率为 31.7/100000（95%CI 30.2，33.1），在 2010-2014 年达到峰值。不同登记处的发病率差异无显著差异。在所有年龄组中，女孩的发病率均高于男孩。女孩的发病率在 2 岁和 14-15 岁时达到峰值。在整个研究期间，0-3 岁男孩的发病率呈下降趋势，而 14-17 岁女孩和 4-7 岁男孩的发病率在 2000-2013 年呈上升趋势。
JIA 的发病率不仅相对于世界其他地区非常高，而且高于芬兰之前的报告。发病率因地区和年份而异，但在研究期间并未在末期高于初期。
