2004 - 2022年南非农村地区中年家庭粮食不安全状况及其随后的记忆功能和衰退率
Mid-Life Household Food Insecurity and Subsequent Memory Function and Rate of Decline in Rural South Africa, 2004-2022.
作者信息
Yu Xuexin, Gill Audra, Chakraborty Rishika, Kabudula Chodziwadziwa W, Wagner Ryan G, Bassil Darina T, Farrell Meagan T, Tollman Stephen M, Kahn Kathleen, Rosenberg Molly S, Kobayashi Lindsay C
机构信息
Center for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA,
Center for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
出版信息
Neuroepidemiology. 2025;59(2):110-119. doi: 10.1159/000539578. Epub 2024 Jun 10.
INTRODUCTION
We aimed to investigate mid-life food insecurity over time in relation to subsequent memory function and rate of decline in Agincourt, rural South Africa.
METHODS
Data from the longitudinal Agincourt Health and Socio-Demographic Surveillance System (Agincourt HDSS) were linked to the population-representative Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI). Food insecurity (yes vs. no) and food insecurity intensity (never/rarely/sometimes vs. often/very often) in the past month were assessed every 3 years from 2004 to 2013 in Agincourt HDSS. Cumulative exposure to each food insecurity measure was operationalized as 0, 1, and ≥2 time points. Episodic memory was assessed from 2014/15 to 2021/22 in HAALSI. Mixed-effects linear regression models were fitted to investigate the associations of each food insecurity measure with memory function and rate of decline over time.
RESULTS
A total of 3,186 participants (mean age [SD] in 2004: 53 [12.87]; range: 30-96) were included and 1,173 (36%) participants experienced food insecurity in 2004, while this figure decreased to 490 (15%) in 2007, 489 (15%) in 2010, and 150 (5%) in 2013. Experiencing food insecurity at one time point (vs. never) from 2004 to 2013 was associated with lower baseline memory function (β = -0.095; 95% CI: -0.159 to -0.032) in 2014/15 but not rate of memory decline. Higher intensity of food insecurity at ≥2 time points (vs. never) was associated with lower baseline memory function (β = -0.154, 95% CI: -0.338 to 0.028), although the estimate was imprecise. Other frequencies of food insecurity and food insecurity intensity were not associated with memory function or decline in the fully adjusted models.
CONCLUSION
In this setting, mid-life food insecurity may be a risk factor for lower later-life memory function, but not decline.
INTRODUCTION
We aimed to investigate mid-life food insecurity over time in relation to subsequent memory function and rate of decline in Agincourt, rural South Africa.
METHODS
Data from the longitudinal Agincourt Health and Socio-Demographic Surveillance System (Agincourt HDSS) were linked to the population-representative Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI). Food insecurity (yes vs. no) and food insecurity intensity (never/rarely/sometimes vs. often/very often) in the past month were assessed every 3 years from 2004 to 2013 in Agincourt HDSS. Cumulative exposure to each food insecurity measure was operationalized as 0, 1, and ≥2 time points. Episodic memory was assessed from 2014/15 to 2021/22 in HAALSI. Mixed-effects linear regression models were fitted to investigate the associations of each food insecurity measure with memory function and rate of decline over time.
RESULTS
A total of 3,186 participants (mean age [SD] in 2004: 53 [12.87]; range: 30-96) were included and 1,173 (36%) participants experienced food insecurity in 2004, while this figure decreased to 490 (15%) in 2007, 489 (15%) in 2010, and 150 (5%) in 2013. Experiencing food insecurity at one time point (vs. never) from 2004 to 2013 was associated with lower baseline memory function (β = -0.095; 95% CI: -0.159 to -0.032) in 2014/15 but not rate of memory decline. Higher intensity of food insecurity at ≥2 time points (vs. never) was associated with lower baseline memory function (β = -0.154, 95% CI: -0.338 to 0.028), although the estimate was imprecise. Other frequencies of food insecurity and food insecurity intensity were not associated with memory function or decline in the fully adjusted models.
CONCLUSION
In this setting, mid-life food insecurity may be a risk factor for lower later-life memory function, but not decline.
引言
我们旨在研究南非农村阿金库尔地区中年时期的粮食不安全状况随时间推移与随后的记忆功能及衰退率之间的关系。
方法
纵向的阿金库尔健康与社会人口监测系统（Agincourt HDSS）的数据与具有人口代表性的《非洲健康与老龄化：南非一个深入社区的纵向研究》（HAALSI）相链接。2004年至2013年期间，每3年在阿金库尔健康与社会人口监测系统中评估过去一个月的粮食不安全状况（是与否）以及粮食不安全强度（从不/很少/有时与经常/非常经常）。每种粮食不安全状况的累积暴露情况被设定为0、1和≥2个时间点。2014/15年至2021/22年期间在HAALSI中评估情景记忆。采用混合效应线性回归模型来研究每种粮食不安全状况与记忆功能及随时间衰退率之间的关联。
结果
共纳入3186名参与者（2004年的平均年龄[标准差]：53[12.87]；范围：30 - 96岁），2004年有1173名（36%）参与者经历过粮食不安全，而这一数字在2007年降至490名（15%），2010年为489名（15%），2013年为150名（5%）。2004年至2013年期间在一个时间点经历过粮食不安全（与从未经历过相比）与2014/15年较低的基线记忆功能相关（β = -0.095；95%置信区间：-0.159至-0.032），但与记忆衰退率无关。在≥2个时间点粮食不安全强度较高（与从未经历过相比）与较低的基线记忆功能相关（β = -0.154，95%置信区间：-0.338至0.028），尽管该估计不太精确。在完全调整模型中，其他粮食不安全频率和粮食不安全强度与记忆功能或衰退无关。
结论
在这种情况下，中年时期的粮食不安全可能是晚年记忆功能较低的一个风险因素，但不是记忆衰退的风险因素。
引言
我们旨在研究南非农村阿金库尔地区中年时期的粮食不安全状况随时间推移与随后的记忆功能及衰退率之间的关系。
方法
纵向的阿金库尔健康与社会人口监测系统（Agincourt HDSS）的数据与具有人口代表性的《非洲健康与老龄化：南非一个深入社区的纵向研究》（HAALSI）相链接。2004年至2013年期间，每3年在阿金库尔健康与社会人口监测系统中评估过去一个月的粮食不安全状况（是与否）以及粮食不安全强度（从不/很少/有时与经常/非常经常）。每种粮食不安全状况的累积暴露情况被设定为0、1和≥2个时间点。2014/15年至2021/22年期间在HAALSI中评估情景记忆。采用混合效应线性回归模型来研究每种粮食不安全状况与记忆功能及随时间衰退率之间的关联。
结果
共纳入3186名参与者（2004年的平均年龄[标准差]：53[12.87]；范围：30 - 96岁），2004年有1173名（36%）参与者经历过粮食不安全，而这一数字在2007年降至490名（15%），2010年为489名（15%），2013年为150名（5%）。2004年至2013年期间在一个时间点经历过粮食不安全（与从未经历过相比）与2014/15年较低的基线记忆功能相关（β = -0.095；95%置信区间：-0.159至-0.032），但与记忆衰退率无关。在≥2个时间点粮食不安全强度较高（与从未经历过相比）与较低的基线记忆功能相关（β = -0.154，95%置信区间：-0.338至0.028），尽管该估计不太精确。在完全调整模型中，其他粮食不安全频率和粮食不安全强度与记忆功能或衰退无关。
结论
在这种情况下，中年时期的粮食不安全可能是晚年记忆功能较低的一个风险因素，但不是记忆衰退的风险因素。
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