Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, Azinhaga de Santa Comba, Pólo III - Pólo das Ciências da Saúde, Coimbra, 3000-548, Portugal; Univ Coimbra, Institute of Biophysics, Faculty of Medicine, Azinhaga de Santa Comba, Pólo III - Pólo das Ciências da Saúde, Coimbra, 3000-548, Portugal; Univ Coimbra, Coimbra Chemistry Centre - Institute of Molecular Sciences and Department of Chemistry, Rua Larga, Coimbra, 3004-535, Portugal.
Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, Azinhaga de Santa Comba, Pólo III - Pólo das Ciências da Saúde, Coimbra, 3000-548, Portugal; Univ Coimbra, Institute of Biophysics, Faculty of Medicine, Azinhaga de Santa Comba, Pólo III - Pólo das Ciências da Saúde, Coimbra, 3000-548, Portugal; Univ Coimbra, Institute of Experimental Pathology, Faculty of Medicine, Azinhaga de Santa Comba, Pólo III - Pólo das Ciências da Saúde, Coimbra, 3000-548, Portugal; Univ Coimbra, Institute of Integrated Clinical Practice and Laboratory for Evidence-based Science and Precision Dentistry, Faculty of Medicine, Av. Bissaya Barreto, Bloco de Celas, 3000-075 Coimbra, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Rua Larga, Coimbra, 3004-504, Portugal; Clinical Academic Center of Coimbra (CACC), Praceta Professor Mota Pinto, Coimbra, 3004-561, Portugal; Univ Coimbra, CEMMPRE, ARISE, Pinhal de Marrocos, 3030-788 Coimbra, Portugal.
Photodiagnosis Photodyn Ther. 2024 Aug;48:104242. doi: 10.1016/j.pdpdt.2024.104242. Epub 2024 Jun 8.
This systematic review assessed the effectiveness of photodynamic therapy (PDT) in patients with recurrent oral squamous cell carcinoma (OSCC).
Clinical studies on recurrent OSCC treated with PDT alone were included. Combined treatment strategies were excluded. The search was performed on Medline/Pubmed, Cochrane Library, Embase, Web of Science and ClinicalTrials.gov, manual search, and grey literature.
The eleven included studies were observational. The risk of bias and methodological quality were evaluated using the Newcastle-Ottawa Quality Assessment Scale. The studies reported the use of hematoporphyrin derivative, Photofrin, Foscan and 5-aminolevulinic acid. Data on treatment response and survival was collected. Secondarily, postoperative courses and patient's quality of life/acceptance were reported whenever available. Photofrin and Foscan were the most used photosensitisers, with more complete responses. Lesions responding less favourably were on posterior regions or deep-seated in the tissue.
Although treatment response differs between treatment protocols, PDT stands as a viable treatment option to be considered, as it can achieve therapeutic results and disease-free, long-lasting periods. Partial treatment responses may be of interest when achieving eligibility for other treatment strategies. Despite this study's limitations, which considered four photosensitisers, Photofrin was the most used but more recent photosensitisers like Foscan have greater chemical stability, tissue penetration, and may be more efficacious on recurrent OSCC.
本系统评价评估了光动力疗法（PDT）在复发性口腔鳞状细胞癌（OSCC）患者中的疗效。
纳入了单独使用 PDT 治疗复发性 OSCC 的临床研究。排除了联合治疗策略。检索了 Medline/Pubmed、Cochrane 图书馆、Embase、Web of Science 和 ClinicalTrials.gov、手动搜索和灰色文献。
纳入的 11 项研究为观察性研究。使用纽卡斯尔-渥太华质量评估量表评估了偏倚风险和方法学质量。研究报告了使用血卟啉衍生物、Photofrin、Foscan 和 5-氨基酮戊酸。收集了治疗反应和生存数据。其次，只要有报道，就会报告术后疗程和患者的生活质量/接受度。Photofrin 和 Foscan 是最常用的光敏剂，反应更完全。反应较差的病变位于后部区域或组织深部。
尽管不同治疗方案的治疗反应不同，但 PDT 作为一种可行的治疗选择值得考虑，因为它可以实现治疗效果和无疾病、持久的缓解期。当达到其他治疗策略的资格标准时，部分治疗反应可能会引起关注。尽管本研究存在局限性，仅考虑了四种光敏剂，但 Photofrin 是最常用的光敏剂，但最近的光敏剂如 Foscan 具有更高的化学稳定性、组织穿透力，并且可能对复发性 OSCC 更有效。
