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基于转录组测序的变应性鼻炎研究进展

[Progress of allergic rhinitis research based on transcriptome sequencing].

作者信息

Zhang Haoxiang, Wang Yanjie, Cheng Fengli, An Yunfang, Zhao Changqing

机构信息

Department of Otorhinolaryngology Head and Neck Surgery,the Second Hospital,Shanxi Medical University,Key Research Laboratory of Airway Neuroimmunology,Taiyuan,030001,China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Jun;38(6):556-560. doi: 10.13201/j.issn.2096-7993.2024.06.019.

Abstract

Traditional studies on allergic rhinitis(AR) have mainly adopted animal models and biomolecular approaches. In addition, the advent of transcriptome sequencing technology is promoting the development of AR at the genetic level. Recently, many scholars have focused on the role of common RNA in the pathogenesis of AR, suggesting that breakthroughs have been made in the field of AR bioinformatics analysis. This review aims to summarize the research advances in AR, the development of transcriptome sequencing technology, and the application of transcriptome sequencing in AR, in order to explore potential drug targets for AR treatment and provide new insights into precision medicine.

摘要

传统的变应性鼻炎(AR)研究主要采用动物模型和生物分子方法。此外,转录组测序技术的出现正在推动AR在基因水平上的发展。最近,许多学者关注常见RNA在AR发病机制中的作用,表明在AR生物信息学分析领域已取得突破。本综述旨在总结AR的研究进展、转录组测序技术的发展以及转录组测序在AR中的应用,以探索AR治疗的潜在药物靶点,并为精准医学提供新的见解。

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