Yu Li-Hua, Zhang Ge-Lin
College of Arts and Sports, Hanyang University, Olympic Gym, 222, Wangsimni-Ro, Seongdong-Gu, Seoul, South Korea.
Changsha University of Science and Technology, No. 960, Section 2, Wanjiali South Road, Tianxin District, Changsha City, Hunan Province, China.
J Cardiovasc Transl Res. 2024 Jun 10. doi: 10.1007/s12265-024-10530-w.
Recent research shows exercise is good for heart health, emphasizing the importance of physical activity. Sedentary behavior increases the risk of cardiovascular disease, while exercise can help prevent and treat it. Additionally, physical exercise can modulate the expression of lncRNAs, influencing cardiovascular disease progression. Therefore, understanding this relationship could help identify prospective biomarkers and therapeutic targets pertaining to cardiovascular ailments. This review has underscored recent advancements concerning the potential biomarkers of lncRNAs in cardiovascular diseases, while also summarizing existing knowledge regarding dysregulated lncRNAs and their plausible molecular mechanisms. Additionally, we have contributed novel perspectives on the underlying mechanisms of lncRNAs, which hold promise as potential biomarkers and therapeutic targets for cardiovascular conditions. The knowledge imparted in this review may prove valuable in guiding the design of future investigations and furthering the understanding of lncRNAs as diagnostic, prognostic, and therapeutic biomarkers for cardiovascular diseases.
近期研究表明,运动对心脏健康有益,强调了身体活动的重要性。久坐行为会增加心血管疾病的风险,而运动有助于预防和治疗心血管疾病。此外,体育锻炼可以调节长链非编码RNA(lncRNAs)的表达,影响心血管疾病的进展。因此,了解这种关系有助于识别与心血管疾病相关的潜在生物标志物和治疗靶点。本综述强调了lncRNAs在心血管疾病中作为潜在生物标志物的最新进展,同时总结了关于lncRNAs失调及其可能的分子机制的现有知识。此外,我们还对lncRNAs的潜在机制提出了新的观点,这些机制有望成为心血管疾病的潜在生物标志物和治疗靶点。本综述中传授的知识可能对指导未来研究的设计以及加深对lncRNAs作为心血管疾病诊断、预后和治疗生物标志物的理解具有重要价值。