Sawamura N, Funaki Y, Takahashi S, Yokoyama S, Fujita J, Futami H, Sasaki Y, Yoshioka S, Sakurai M, Eguchi K
Gan To Kagaku Ryoho. 1985 Apr;12(4):943-6.
The effect of high-dose metoclopramide (2 mg/kg, 4 times every 2 hours) on the emesis of patients treated with CDDP (80 mg/m2) was examined by randomized control trial. The above metoclopramide regimen significantly suppressed the frequency of vomiting on the day of CDDP administration. The duration of nausea and anorexia after CDDP treatment was also shortened by high-dose metoclopramide administration.
通过随机对照试验，研究了大剂量甲氧氯普胺（2毫克/千克，每2小时4次）对接受顺铂（80毫克/平方米）治疗的患者呕吐的影响。上述甲氧氯普胺治疗方案显著抑制了顺铂给药当天的呕吐频率。大剂量给予甲氧氯普胺也缩短了顺铂治疗后恶心和食欲不振的持续时间。
