肾上腺素和去甲肾上腺素对分离的胰岛免疫反应性胰岛素分泌的影响。

Effect of epinephrine and norepinephrine on immuno-reactive insulin secretion from isolated islets of Langerhans.

作者信息

Mukherjee B, Chatterjee A K, Bhatia G S, Mukherjee S K

出版信息

Biochem Pharmacol. 1985 Apr 1;34(7):985-7. doi: 10.1016/0006-2952(85)90600-8.

Abstract

Earlier studies have demonstrated the inhibitory nature of epinephrine and norepinephrine on pancreatic insulin release. The present study reports their effect on beta-cell IRI release in an isolated islet system. Results show that epinephrine and norepinephrine inhibit islet-IRI release at the 100-10 microM level. The alpha adrenergic blocker phentolamine (100 microM) but not the beta adrenergic blocker propranolol (100 microM) can reverse this catecholamine induced inhibition of islet-IRI release. This clearly suggests that epinephrine and norepinephrine inhibit insulin release via alpha-adrenergic pathway.

摘要

早期研究已证明肾上腺素和去甲肾上腺素对胰腺胰岛素释放具有抑制作用。本研究报告了它们在分离的胰岛系统中对β细胞IRI释放的影响。结果显示，肾上腺素和去甲肾上腺素在100 - 10微摩尔水平可抑制胰岛IRI释放。α肾上腺素能阻滞剂酚妥拉明（100微摩尔）可逆转这种儿茶酚胺诱导的胰岛IRI释放抑制，而β肾上腺素能阻滞剂普萘洛尔（100微摩尔）则不能。这清楚地表明，肾上腺素和去甲肾上腺素通过α肾上腺素能途径抑制胰岛素释放。