Bacher S, Kraupp O, Beck A, Skoda H, Raberger G
Arzneimittelforschung. 1985;35(1A):288-91.
Vasodilators were characterized on the basis of their first-dose effect on systolic and diastolic blood pressure, heart rate, on the product of heart rate and systolic blood pressure and on plasma renin activity (PRA) in conscious normotensive dogs. The compounds were given orally to the animals and the effects were studied over a period of 4 h. The arterial vasodilators (propyldazine, dihydralazine and labetalol) caused a marked reduction of systolic and diastolic blood pressure with excessive stimulation of the sympathetic nervous system, leading to an increase in myocardial oxygen demand. The blood pressure effect of urapidil and prazosin resembled more the pattern seen with typical venous dilators (molsidomine and nitrates) and was not accompanied by significant increases in heart rate and in PRA. Hence, the magnitude of diastolic blood pressure reduction seems to be an essential determinant of reflex counterregulation. The results prove that some few parameters can give information about the overall pattern of hemodynamic effects of vasodilators.
根据血管扩张剂对清醒正常血压犬的收缩压和舒张压、心率、心率与收缩压的乘积以及血浆肾素活性（PRA）的首剂效应来对其进行表征。将这些化合物经口给予动物，并在4小时内研究其效应。动脉血管扩张剂（丙嗪、双肼屈嗪和拉贝洛尔）可导致收缩压和舒张压显著降低，同时过度刺激交感神经系统，导致心肌需氧量增加。乌拉地尔和哌唑嗪的血压效应更类似于典型静脉扩张剂（吗多明和硝酸盐）的模式，且心率和PRA无显著增加。因此，舒张压降低的幅度似乎是反射性反调节的一个重要决定因素。结果证明，少数几个参数就能提供有关血管扩张剂血液动力学效应总体模式的信息。
